%0 Journal Article
%A Robbins, Hilary A
%A Ferreiro-Iglesias, Aida
%A Waterboer, Tim
%A Brenner, Nicole
%A Nygard, Mari
%A Bender, Noemi
%A Schroeder, Lea
%A Hildesheim, Allan
%A Pawlita, Michael
%A D'Souza, Gypsyamber
%A Visvanathan, Kala
%A Langseth, Hilde
%A Schlecht, Nicolas F
%A Tinker, Lesley F
%A Agalliu, Ilir
%A Wassertheil-Smoller, Sylvia
%A Ness-Jensen, Eivind
%A Hveem, Kristian
%A Grioni, Sara
%A Kaaks, Rudolf
%A Sánchez, Maria-Jose
%A Weiderpass, Elisabete
%A Giles, Graham G
%A Milne, Roger L
%A Cai, Qiuyin
%A Blot, William J
%A Zheng, Wei
%A Weinstein, Stephanie J
%A Albanes, Demetrius
%A Huang, Wen-Yi
%A Freedman, Neal D
%A Kreimer, Aimée R
%A Johansson, Mattias
%A Brennan, Paul
%T Absolute Risk of Oropharyngeal Cancer After an HPV16-E6 Serology Test and Potential Implications for Screening: Results From the Human Papillomavirus Cancer Cohort Consortium.
%J Journal of clinical oncology
%V 40
%N 31
%@ 0732-183X
%C Alexandria, Va.
%I American Society of Clinical Oncology
%M DKFZ-2022-02631
%P 3613 - 3622
%D 2022
%X Seropositivity for the HPV16-E6 oncoprotein is a promising marker for early detection of oropharyngeal cancer (OPC), but the absolute risk of OPC after a positive or negative test is unknown.We constructed an OPC risk prediction model that integrates (1) relative odds of OPC for HPV16-E6 serostatus and cigarette smoking from the human papillomavirus (HPV) Cancer Cohort Consortium (HPVC3), (2) US population risk factor data from the National Health Interview Survey, and (3) US sex-specific population rates of OPC and mortality.The nine HPVC3 cohorts included 365 participants with OPC with up to 10 years between blood draw and diagnosis and 5,794 controls. The estimated 10-year OPC risk for HPV16-E6 seropositive males at age 50 years was 17.4
%K Male
%K Female
%K Humans
%K Middle Aged
%K Papillomaviridae
%K Alphapapillomavirus
%K Human papillomavirus 16: genetics
%K Papillomavirus Infections: complications
%K Papillomavirus Infections: diagnosis
%K Papillomavirus Infections: epidemiology
%K Antibodies, Viral
%K Early Detection of Cancer
%K Oropharyngeal Neoplasms: diagnosis
%K Oropharyngeal Neoplasms: epidemiology
%K Oncogene Proteins, Viral
%K Antibodies, Viral (NLM Chemicals)
%K Oncogene Proteins, Viral (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35700419
%2 pmc:PMC9622695
%R 10.1200/JCO.21.01785
%U https://inrepo02.dkfz.de/record/182410