TY  - JOUR
AU  - Robbins, Hilary A
AU  - Ferreiro-Iglesias, Aida
AU  - Waterboer, Tim
AU  - Brenner, Nicole
AU  - Nygard, Mari
AU  - Bender, Noemi
AU  - Schroeder, Lea
AU  - Hildesheim, Allan
AU  - Pawlita, Michael
AU  - D'Souza, Gypsyamber
AU  - Visvanathan, Kala
AU  - Langseth, Hilde
AU  - Schlecht, Nicolas F
AU  - Tinker, Lesley F
AU  - Agalliu, Ilir
AU  - Wassertheil-Smoller, Sylvia
AU  - Ness-Jensen, Eivind
AU  - Hveem, Kristian
AU  - Grioni, Sara
AU  - Kaaks, Rudolf
AU  - Sánchez, Maria-Jose
AU  - Weiderpass, Elisabete
AU  - Giles, Graham G
AU  - Milne, Roger L
AU  - Cai, Qiuyin
AU  - Blot, William J
AU  - Zheng, Wei
AU  - Weinstein, Stephanie J
AU  - Albanes, Demetrius
AU  - Huang, Wen-Yi
AU  - Freedman, Neal D
AU  - Kreimer, Aimée R
AU  - Johansson, Mattias
AU  - Brennan, Paul
TI  - Absolute Risk of Oropharyngeal Cancer After an HPV16-E6 Serology Test and Potential Implications for Screening: Results From the Human Papillomavirus Cancer Cohort Consortium.
JO  - Journal of clinical oncology
VL  - 40
IS  - 31
SN  - 0732-183X
CY  - Alexandria, Va.
PB  - American Society of Clinical Oncology
M1  - DKFZ-2022-02631
SP  - 3613 - 3622
PY  - 2022
AB  - Seropositivity for the HPV16-E6 oncoprotein is a promising marker for early detection of oropharyngeal cancer (OPC), but the absolute risk of OPC after a positive or negative test is unknown.We constructed an OPC risk prediction model that integrates (1) relative odds of OPC for HPV16-E6 serostatus and cigarette smoking from the human papillomavirus (HPV) Cancer Cohort Consortium (HPVC3), (2) US population risk factor data from the National Health Interview Survey, and (3) US sex-specific population rates of OPC and mortality.The nine HPVC3 cohorts included 365 participants with OPC with up to 10 years between blood draw and diagnosis and 5,794 controls. The estimated 10-year OPC risk for HPV16-E6 seropositive males at age 50 years was 17.4
KW  - Male
KW  - Female
KW  - Humans
KW  - Middle Aged
KW  - Papillomaviridae
KW  - Alphapapillomavirus
KW  - Human papillomavirus 16: genetics
KW  - Papillomavirus Infections: complications
KW  - Papillomavirus Infections: diagnosis
KW  - Papillomavirus Infections: epidemiology
KW  - Antibodies, Viral
KW  - Early Detection of Cancer
KW  - Oropharyngeal Neoplasms: diagnosis
KW  - Oropharyngeal Neoplasms: epidemiology
KW  - Oncogene Proteins, Viral
KW  - Antibodies, Viral (NLM Chemicals)
KW  - Oncogene Proteins, Viral (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:35700419
C2  - pmc:PMC9622695
DO  - DOI:10.1200/JCO.21.01785
UR  - https://inrepo02.dkfz.de/record/182410
ER  -