TY  - JOUR
AU  - Hoffmann, Ingrid
TI  - Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication-Impact on Cancer
JO  - Cells
VL  - 11
IS  - 5
SN  - 2073-4409
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-02680
SP  - 786
PY  - 2022
N1  - #LA:F045#
AB  - Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle. Aberration of the centrosome number is common in human tumors. At the core of centriole duplication is the conserved polo-like kinase 4, Plk4, and two structural proteins, STIL and Sas-6. In this review, I summarize and discuss developments in our understanding of the first steps of centriole duplication and their regulation
LB  - PUB:(DE-HGF)16
DO  - DOI:https://doi.org/10.3390/cells11050786
UR  - https://inrepo02.dkfz.de/record/182485
ER  -