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| Home > Publications database > DOSE CALCULATION FOR ULTRA-HIGH DOSERATE RADIOTHERAPY |
| Master Thesis | DKFZ-2022-02713 |
2022
Abstract: The FLASH effect consists of an apparent reduction in the toxicity of radiation by increasing the dose rate, which has been observed in recent studies, conducted over thelast decade, mainly with electrons. It has also been observed with photons and protons.The effect is manifested as a reduction of toxicities in healthy tissue while preserving thedamage to tumor tissue relative to other radiation treatment methods. Most of the positive results have been obtained on tissues from animals, whereas only one human patienthas been treated in the framework of a clinical study. The cellular biological mechanismby which this effect is triggered is uncertain. Thus, in vitro studies are needed to advance this line of research and thus, in the future, take advantage of this phenomenon inreal clinical cases. Chapter 1 is a compilation of the physical basics on which this workhas been carried out, where the basic principles of radiotherapy and proton therapy areintroduced. In Chapter 1, the physical and biological processes by which radiation interacts with tissue and causes cell death are explained. The second part of the chapterpresents the characteristics of the proton therapy and the techniques used and explainshow this technique differs from the rest radiotherapeutic techniques that use other typesof particles. Chapter 2 is a review of the articles published on FLASH, that is, of the results that have been obtained, the cellular biological theory underlying this phenomenonand the dosimetric conditions necessary to witness this effect. The simulations carriedout with open-source treatment planning software matRad, are described in Chapter 3,which explains the objectives of the project and the idea of a combined FLASH-IMPTmulti-beam irradiation treatment plan with a homogeneous dose distribution, also addinga description of the respective software. Chapter 4 of the thesis presents the results obtained in the investigation. The respective dose profiles, dose maps and pictures werecreated in matRad. The codes were developed in MATLAB programming and numericcomputing platform. All codes of implementation development have been hosted in theGithub repository. Chapter 5 gives a brief discussion of results.
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