%0 Journal Article
%A Kuznia, Sabine
%A Czock, David
%A Kopp-Schneider, Annette
%A Caspari, Reiner
%A Fischer, Harald
%A Laetsch, Dana Clarissa
%A Slavic, Marija
%A Brenner, Hermann
%A Schöttker, Ben
%T Efficacy and Safety of a Personalized Vitamin D3 Loading Dose Followed by Daily 2000 IU in Colorectal Cancer Patients with Vitamin D Insufficiency: Interim Analysis of a Randomized Controlled Trial.
%J Nutrients
%V 14
%N 21
%@ 2072-6643
%C Basel
%I MDPI
%M DKFZ-2022-02739
%P 4546
%D 2022
%Z #EA:C070#LA:C070#LA:C120#
%X A personalized vitamin D3 loading dose has not yet been tested in cancer patients. This interim analysis of the randomized, placebo-controlled VICTORIA trial analyzed the first recruited 74 German adults with nonmetastatic colorectal cancer, a tumor surgery within the past year, and 25-hydroxyvitamin D levels (25(OH)D) < 50 nmol/L. Study participants received a loading dose tailored for a baseline 25(OH)D level and BMI in the first 11 days, followed by a maintenance dose of 2000 IU of vitamin D3 daily until end of trial week 12. The mean 25(OH)D levels were 27.6, 31.0, and 34.1 nmol/L in the placebo group and 25.9, 63.1, and 75.5 nmol/L in the verum group during screening, visit 1 (end of loading dose), and visit 2 (end of maintenance dose), respectively. The prevalence of 25(OH)D) ≥ 50 nmol/L at visits 1 and 2 was 3.5
%K bolus (Other)
%K calcium (Other)
%K colorectal cancer (Other)
%K efficacy (Other)
%K loading dose (Other)
%K personalized medicine (Other)
%K randomized controlled trial (Other)
%K safety (Other)
%K treatment regimen (Other)
%K vitamin D (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36364809
%R 10.3390/nu14214546
%U https://inrepo02.dkfz.de/record/182558