TY  - JOUR
AU  - Kuznia, Sabine
AU  - Czock, David
AU  - Kopp-Schneider, Annette
AU  - Caspari, Reiner
AU  - Fischer, Harald
AU  - Laetsch, Dana Clarissa
AU  - Slavic, Marija
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Efficacy and Safety of a Personalized Vitamin D3 Loading Dose Followed by Daily 2000 IU in Colorectal Cancer Patients with Vitamin D Insufficiency: Interim Analysis of a Randomized Controlled Trial.
JO  - Nutrients
VL  - 14
IS  - 21
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-02739
SP  - 4546
PY  - 2022
N1  - #EA:C070#LA:C070#LA:C120#
AB  - A personalized vitamin D3 loading dose has not yet been tested in cancer patients. This interim analysis of the randomized, placebo-controlled VICTORIA trial analyzed the first recruited 74 German adults with nonmetastatic colorectal cancer, a tumor surgery within the past year, and 25-hydroxyvitamin D levels (25(OH)D) < 50 nmol/L. Study participants received a loading dose tailored for a baseline 25(OH)D level and BMI in the first 11 days, followed by a maintenance dose of 2000 IU of vitamin D3 daily until end of trial week 12. The mean 25(OH)D levels were 27.6, 31.0, and 34.1 nmol/L in the placebo group and 25.9, 63.1, and 75.5 nmol/L in the verum group during screening, visit 1 (end of loading dose), and visit 2 (end of maintenance dose), respectively. The prevalence of 25(OH)D) ≥ 50 nmol/L at visits 1 and 2 was 3.5
KW  - bolus (Other)
KW  - calcium (Other)
KW  - colorectal cancer (Other)
KW  - efficacy (Other)
KW  - loading dose (Other)
KW  - personalized medicine (Other)
KW  - randomized controlled trial (Other)
KW  - safety (Other)
KW  - treatment regimen (Other)
KW  - vitamin D (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36364809
DO  - DOI:10.3390/nu14214546
UR  - https://inrepo02.dkfz.de/record/182558
ER  -