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| 100 | 1 | _ | |a Kuznia, Sabine |0 P:(DE-He78)a1d1b323625dcfa155b477a646cbda52 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Efficacy and Safety of a Personalized Vitamin D3 Loading Dose Followed by Daily 2000 IU in Colorectal Cancer Patients with Vitamin D Insufficiency: Interim Analysis of a Randomized Controlled Trial. |
| 260 | _ | _ | |a Basel |c 2022 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1668427340_28554 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 520 | _ | _ | |a A personalized vitamin D3 loading dose has not yet been tested in cancer patients. This interim analysis of the randomized, placebo-controlled VICTORIA trial analyzed the first recruited 74 German adults with nonmetastatic colorectal cancer, a tumor surgery within the past year, and 25-hydroxyvitamin D levels (25(OH)D) < 50 nmol/L. Study participants received a loading dose tailored for a baseline 25(OH)D level and BMI in the first 11 days, followed by a maintenance dose of 2000 IU of vitamin D3 daily until end of trial week 12. The mean 25(OH)D levels were 27.6, 31.0, and 34.1 nmol/L in the placebo group and 25.9, 63.1, and 75.5 nmol/L in the verum group during screening, visit 1 (end of loading dose), and visit 2 (end of maintenance dose), respectively. The prevalence of 25(OH)D) ≥ 50 nmol/L at visits 1 and 2 was 3.5% and 17.4% in the placebo group and 80.0% and 100% in the verum group. No events of 25(OH)D > 150 nmol/L or hypercalcemia were observed. Hypercalciuria events at visit 1 (n = 5 in verum and n = 1 in the placebo group; p = 0.209) receded after discontinuation of the study medication. The personalized loading dose effectively and safely increased the 25(OH)D levels, and 2000 IU of vitamin D3 daily sustained the achieved levels. |
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| 650 | _ | 7 | |a bolus |2 Other |
| 650 | _ | 7 | |a calcium |2 Other |
| 650 | _ | 7 | |a colorectal cancer |2 Other |
| 650 | _ | 7 | |a efficacy |2 Other |
| 650 | _ | 7 | |a loading dose |2 Other |
| 650 | _ | 7 | |a personalized medicine |2 Other |
| 650 | _ | 7 | |a randomized controlled trial |2 Other |
| 650 | _ | 7 | |a safety |2 Other |
| 650 | _ | 7 | |a treatment regimen |2 Other |
| 650 | _ | 7 | |a vitamin D |2 Other |
| 700 | 1 | _ | |a Czock, David |0 0000-0003-1217-5134 |b 1 |
| 700 | 1 | _ | |a Kopp-Schneider, Annette |0 P:(DE-He78)bb6a7a70f976eb8df1769944bf913596 |b 2 |u dkfz |
| 700 | 1 | _ | |a Caspari, Reiner |b 3 |
| 700 | 1 | _ | |a Fischer, Harald |b 4 |
| 700 | 1 | _ | |a Laetsch, Dana Clarissa |0 P:(DE-He78)358cd16fe1dd16be6e4eaf0e76e5ad57 |b 5 |
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| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 7 |e Last author |u dkfz |
| 700 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.3390/nu14214546 |g Vol. 14, no. 21, p. 4546 - |0 PERI:(DE-600)2518386-2 |n 21 |p 4546 |t Nutrients |v 14 |y 2022 |x 2072-6643 |
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