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@ARTICLE{Rajtmajerov:182567,
      author       = {M. Rajtmajerová and A. Trailin and V. Liška and K.
                      Hemminki$^*$ and F. Ambrozkiewicz},
      title        = {{L}ong {N}on-{C}oding {RNA} and micro{RNA} {I}nterplay in
                      {C}olorectal {C}ancer and {T}heir {E}ffect on the {T}umor
                      {M}icroenvironment.},
      journal      = {Cancers},
      volume       = {14},
      number       = {21},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-02748},
      pages        = {5450},
      year         = {2022},
      abstract     = {As the current staging and grading systems are not
                      sufficient to stratify patients for therapy and predict the
                      outcome of the disease, there is an urgent need to
                      understand cancer in its complexity. The mutual relationship
                      between tumour and immune or stromal cells leads to rapid
                      evolution and subsequent genetic and epigenetic changes.
                      Immunoscore has been introduced as a diagnostic tool for
                      colorectal cancer (CRC) only recently, emphasising the role
                      of the specific tumor microenvironment in patient's
                      prognosis and overall outcome. Despite the fact that
                      non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and
                      long non-coding RNAs (lncRNAs), cannot be translated into
                      proteins, they significantly affect cell's transcriptome and
                      translatome. miRNA binding to mRNA efficiently blocks its
                      translation and leads to mRNA destruction. On the other
                      hand, miRNAs can be bound by lncRNAs or circular RNAs
                      (circRNAs), which prevents them from interfering with
                      translation. In this way, ncRNAs create a multi-step network
                      that regulates the cell's translatome. ncRNAs are also shed
                      by the cell as exogenous RNAs and they are also found in
                      exosomes, suggesting their role in intercellular
                      communication. Hence, these mechanisms affect the tumor
                      microenvironment as much as protein signal molecules. In
                      this review, we provide an insight into the current
                      knowledge of the microenvironment, lncRNAs', and miRNAs'
                      interplay. Understanding mechanisms that underlie the
                      evolution of a tissue as complex as a tumour is crucial for
                      the future success in therapy.},
      subtyp        = {Review Article},
      keywords     = {CAFs (Other) / CRC (Other) / colorectal cancer (Other) /
                      lncRNA (Other) / lymphocytes (Other) / macrophages (Other) /
                      miRNA (Other) / tumor microenvironment (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36358867},
      doi          = {10.3390/cancers14215450},
      url          = {https://inrepo02.dkfz.de/record/182567},
}