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@ARTICLE{Glatting:182569,
      author       = {F. M. Glatting$^*$ and J. Hoppner and H.-U. Kauczor and P.
                      E. Huber$^*$ and C. Kratochwil and F. L. Giesel and U.
                      Haberkorn$^*$ and M. Röhrich},
      title        = {{S}ubclass {A}nalysis of {M}alignant, {I}nflammatory and
                      {D}egenerative {P}athologies {B}ased on {M}ultiple
                      {T}imepoint {FAPI}-{PET} {A}cquisitions {U}sing {FAPI}-02,
                      {FAPI}-46 and {FAPI}-74.},
      journal      = {Cancers},
      volume       = {14},
      number       = {21},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-02750},
      pages        = {5301},
      year         = {2022},
      note         = {#EA:E055#},
      abstract     = {FAPI-PET is a promising imaging technique for various
                      malignant as well as non-malignant pathologies. In a recent
                      retrospective analysis, we evaluated the diagnostic value of
                      repetitive early FAPI-PET-imaging with FAPI-02, FAPI-46 and
                      FAPI-74 for malignant, inflammatory/reactive and
                      degenerative pathologies. Here, we apply a subgroup analysis
                      to that dataset and describe the tracer-wise uptake kinetic
                      behavior of multiple types of FAPI-positive lesions, which
                      are encountered frequently during clinical routine.A total
                      of 24 cancer patients underwent whole-body FAPI-PET scans,
                      and images were acquired at 10, 22, 34, 46 and 58 min after
                      the administration of 150-250 MBq of 68Ga-FAPI tracer
                      molecules (eight patients each regarding FAPI-02, FAPI-46
                      and FAPI-74). Standardized uptake values (SUVmax and
                      SUVmean) of healthy tissues, cancer manifestations and
                      non-malignant lesions were measured and target-to-background
                      ratios (TBR) versus blood and fat were calculated for all
                      acquisition timepoints.Differential uptake behavior over
                      time was observed in several subclasses of malignant
                      lesions, inflammatory/reactive lesions and degenerative
                      lesions. These differences over time were particularly
                      manifested in the direct comparison between the uptakes
                      associated with pancreatic carcinoma (stable or increasing
                      over time) and inflammatory lesions of the pancreas
                      (markedly decreasing over time). Furthermore, marked
                      differences were found between the three tracer variants
                      regarding their time-dependent uptake and TBRs within
                      different subclasses of malignant, inflammatory/reactive and
                      degenerative pathologies.Multiple timepoint FAPI-PET/CT is a
                      promising innovative imaging technique that provides
                      additional imaging information compared to single timepoint
                      imaging. Differences in the kinetic behavior of malignant
                      and benign pathologies can facilitate the interpretation of
                      FAPI-positive lesions.},
      keywords     = {FAPI (Other) / PET (Other) / cancer (Other) / degeneration
                      (Other) / fibroblast activation protein (Other) /
                      inflammation (Other) / pancreatic carcinoma (Other) /
                      pancreatitis (Other)},
      cin          = {E055 / E060},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)E060-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36358720},
      doi          = {10.3390/cancers14215301},
      url          = {https://inrepo02.dkfz.de/record/182569},
}