%0 Journal Article
%A Rühle, Alexander
%A Todorovic, Jovan
%A Spohn, Simon S K
%A Gkika, Eleni
%A Becker, Christoph
%A Knopf, Andreas
%A Zamboglou, Constantinos
%A Sprave, Tanja
%A Werner, Martin
%A Grosu, Anca-Ligia
%A Kayser, Gian
%A Nicolay, Nils
%T Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy.
%J Radiation oncology
%V 17
%N 1
%@ 1748-717X
%C London
%I BioMed Central
%M DKFZ-2022-02787
%P 181
%D 2022
%Z #EA:E055#LA:E055#
%X Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in reduced immune activity, the role of TILs in elderly HNSCC patients may differ compared to younger patients, providing a rationale to study the prognostic role of TILs and immune checkpoints (ICs) in this population.Sixty-three HNSCC patients aged ≥ 65 years undergoing definitive (chemo)radiotherapy between 2010 and 2019 with sufficient material from pre-treatment biopsies were included in the analysis. Immunohistochemical stainings of CD3, CD4, CD8, PD-L1, TIM3, LAG3, TIGIT and CD96, and of osteopontin as an immunosenescence-associated protein were performed. Overall survival (OS) and progression-free survival (PFS) were determined using the Kaplan-Meier method, and Fine-Gray's models were used for locoregional failure (LRF) analyses.While there was no correlation between patient age and IC expression, osteopontin levels correlated with increasing age (r = 0.322, p < 0.05). Two-year OS, PFS, and LRC were 44
%K Elderly (Other)
%K Geriatric (Other)
%K Head-and-neck cancer (Other)
%K Immune checkpoint (Other)
%K Immunosenescence (Other)
%K Radiotherapy (Other)
%K Tumor-infiltrating lymphocytes (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36376922
%R 10.1186/s13014-022-02153-9
%U https://inrepo02.dkfz.de/record/182606