TY  - JOUR
AU  - Rühle, Alexander
AU  - Todorovic, Jovan
AU  - Spohn, Simon S K
AU  - Gkika, Eleni
AU  - Becker, Christoph
AU  - Knopf, Andreas
AU  - Zamboglou, Constantinos
AU  - Sprave, Tanja
AU  - Werner, Martin
AU  - Grosu, Anca-Ligia
AU  - Kayser, Gian
AU  - Nicolay, Nils
TI  - Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy.
JO  - Radiation oncology
VL  - 17
IS  - 1
SN  - 1748-717X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2022-02787
SP  - 181
PY  - 2022
N1  - #EA:E055#LA:E055#
AB  - Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in reduced immune activity, the role of TILs in elderly HNSCC patients may differ compared to younger patients, providing a rationale to study the prognostic role of TILs and immune checkpoints (ICs) in this population.Sixty-three HNSCC patients aged ≥ 65 years undergoing definitive (chemo)radiotherapy between 2010 and 2019 with sufficient material from pre-treatment biopsies were included in the analysis. Immunohistochemical stainings of CD3, CD4, CD8, PD-L1, TIM3, LAG3, TIGIT and CD96, and of osteopontin as an immunosenescence-associated protein were performed. Overall survival (OS) and progression-free survival (PFS) were determined using the Kaplan-Meier method, and Fine-Gray's models were used for locoregional failure (LRF) analyses.While there was no correlation between patient age and IC expression, osteopontin levels correlated with increasing age (r = 0.322, p < 0.05). Two-year OS, PFS, and LRC were 44
KW  - Elderly (Other)
KW  - Geriatric (Other)
KW  - Head-and-neck cancer (Other)
KW  - Immune checkpoint (Other)
KW  - Immunosenescence (Other)
KW  - Radiotherapy (Other)
KW  - Tumor-infiltrating lymphocytes (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36376922
DO  - DOI:10.1186/s13014-022-02153-9
UR  - https://inrepo02.dkfz.de/record/182606
ER  -