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@ARTICLE{Armocida:182614,
author = {B. Armocida and L. Monasta and S. Sawyer and F. Bustreo and
G. Segafredo and G. Castelpietra and L. Ronfani and M.
Pasovic and S. Hay and P. Perel and D. Beran},
collaboration = {GBD 2019 Europe NCDs in {Adolescents Collaborators}},
othercontributors = {B. Armocida and L. Monasta and S. M. Sawyer and F. Bustreo
and G. Segafredo and G. Castelpietra and L. Ronfani and M.
Pasovic and S. I. Hay and D. B. Abila and H. Abolhassani and
M. M. K. Accrombessi and V. Adekanmbi and K. Ahmadi and H.
Al Hamad and M. A. Aldeyab and A. Al-Jumaily and R.
Ancuceanu and C. L. Andrei and T. Andrei and A. Arumugam and
S. Attia and A. Aujayeb and M. Ausloos and J. L. Baker and
F. Barone-Adesi and F. Barra and S. Barteit and S. Basu and
B. T. Baune and Y. Béjot and L. Belo and D. A. Bennett and
B. Bikbov and A. Bikov and O. Blyuss and S. Breitner and H.
Brenner$^*$ and G. Carreras and M. Carvalho and A. L.
Catapano and J. S. Chandan and P. Charalampous and S. Chen
and J. Conde and N. Cruz-Martins and G. Damiani and A.
Dastiridou and A. de la Torre-Luque and M. Dianatinasab and
D. Dias da Silva and A. Douiri and E. Dragioti and L.
Engelbert Bain and A. F. Fagbamigbe and S.-M. Fereshtehnejad
and P. Ferrara and J. M. P. Ferreira de Oliveira and S.
Ferrero and L. Ferro Desideri and F. Fischer and D. A.
Fonseca and P. Gaewkhiew and S. Gaihre and S. Gallus and M.
Gaspar Fonseca and P. S. Gill and J. C. Glasbey and G.
Gorini and V. K. Gupta and M. K. Gurara and J. M. Haro and
M. T. Hasan and R. J. Havmoeller and B. Heibati and M. E.
Hellemons and C. Herteliu and S. Hussain and G. Isola and O.
Johnson and J. B. Jonas and J. J. Jozwiak and M. Jürisson
and Z. Kabir and A. Karch and J. H. Kauppila and G. A.
Kayode and M. A. Khan and K. Khatab and M. Kivimäki and M.
Klugar and J. Klugarová and K. N. Koly and A. Koyanagi and
O. P. Kurmi and D. Kusuma and C. La Vecchia and B. Lacey and
T. Lallukka and D. Lamnisos and B. Langguth and A. O.
Larsson and P. Lauriola and P. H. Lee and M. Leonardi and A.
Li and C. Linehan and R. López-Bueno and S. Lorkowski and
J. A. Loureiro and R. Lunevicius and L. A. Magee and F. G.
Magnani and A. Majeed and K. C. Makris and A. G.
Mathioudakis and M. R. Mathur and J. J. McGrath and R. G.
Menezes and A. A. Mentis and A. Meretoja and T. Mestrovic
and J. Miao Jonasson and T. Miazgowski and A. Mirica and M.
Moccia and S. Mohammed and M. Molokhia and S. Mondello and
U. O. Mueller and F. Mulita and D. Munblit and I. Negoi and
R. I. Negoi and E. Nena and N. M. Noor and C. Nowak and G.
Ntaios and V. E. Nwatah and B. Oancea and A. S. Oguntade and
A. Ortiz and A. Otoiu and A. Padron-Monedero and R.
Palladino and A. Pana and D. Panagiotakos and S. Panda-Jonas
and S. Pardhan and J. Patel and P. Pedersini and J. L.
Peñalvo and U. Pensato and R. B. Pereira and N. Perico and
I.-R. Petcu and S. Polinder and M. J. Postma and M. Rabiee
and N. Rabiee and A. Raggi and S. Rahimzadeh and D. L. Rawaf
and S. Rawaf and F. U. Rehman and G. Remuzzi and A. Riad and
A. Rodriguez and S. Sacco and M. R. Saeb and M. Safdarian
and B. Sathian and D. Sattin and S. Saxena and N. Scarmeas
and W. Schlee and F. Schwendicke and M. Shamsizadeh and N.
T. Sharew and R. Shiri and S. Shivalli and V. Shivarov and
J. P. Silva and C. R. Simpson and S. T. Skou and B. Socea
and I. N. Soyiri and P. Steiropoulos and K. Straif and X.
Sun and R. Tabarés-Seisdedos and A. Thiyagarajan and F.
Topouzis and M. R. Tovani-Palone and T. C. Truelsen and B.
Unim and J. Van den Eynde and T. J. Vasankari and M. Veroux
and S. Villafaina and M. Vinko and F. S. Violante and V.
Volovici and Y. Wang and R. Westerman and M. E. Yadegarfar
and S. Yaya and V. Zadnik and A. Zumla and P. Perel and D.
Beran},
title = {{B}urden of non-communicable diseases among adolescents
aged 10-24 years in the {EU}, 1990-2019: a systematic
analysis of the {G}lobal {B}urden of {D}iseases {S}tudy
2019.},
journal = {The lancet child $\&$ adolescent health},
volume = {6},
number = {6},
issn = {2352-4642},
address = {Kidlington, Oxford},
publisher = {Elsevier},
reportid = {DKFZ-2022-02794},
pages = {367 - 383},
year = {2022},
abstract = {Disability and mortality burden of non-communicable
diseases (NCDs) have risen worldwide; however, the NCD
burden among adolescents remains poorly described in the
EU.Estimates were retrieved from the Global Burden of
Diseases, Injuries, and Risk Factors Study (GBD) 2019.
Causes of NCDs were analysed at three different levels of
the GBD 2019 hierarchy, for which mortality, years of life
lost (YLLs), years lived with disability (YLDs), and
disability-adjusted life-years (DALYs) were extracted.
Estimates, with the $95\%$ uncertainty intervals (UI), were
retrieved for EU Member States from 1990 to 2019, three age
subgroups (10-14 years, 15-19 years, and 20-24 years), and
by sex. Spearman's correlation was conducted between DALY
rates for NCDs and the Socio-demographic Index (SDI) of each
EU Member State.In 2019, NCDs accounted for $86·4\%$
$(95\%$ uncertainty interval 83·5-88·8) of all YLDs and
$38·8\%$ (37·4-39·8) of total deaths in adolescents aged
10-24 years. For NCDs in this age group, neoplasms were the
leading causes of both mortality (4·01 $[95\%$ uncertainty
interval 3·62-4·25] per 100 000 population) and YLLs
(281·78 [254·25-298·92] per 100 000 population), whereas
mental disorders were the leading cause for YLDs (2039·36
[1432·56-2773·47] per 100 000 population) and DALYs
(2040·59 [1433·96-2774·62] per 100 000 population) in all
EU Member States, and in all studied age groups. In 2019,
among adolescents aged 10-24 years, males had a higher
mortality rate per 100 000 population due to NCDs than
females (11·66 [11·04-12·28] vs 7·89 [7·53-8·23]),
whereas females presented a higher DALY rate per 100 000
population due to NCDs (8003·25 [5812·78-10 701·59] vs
6083·91 [4576·63-7857·92]). From 1990 to 2019, mortality
rate due to NCDs in adolescents aged 10-24 years
substantially decreased $(-40·41\%$ [-43·00 to -37·61),
and also the YLL rate considerably decreased $(-40·56\%$
[-43·16 to -37·74]), except for mental disorders (which
increased by $32·18\%$ [1·67 to 66·49]), whereas the YLD
rate increased slightly $(1·44\%$ [0·09 to 2·79]).
Positive correlations were observed between DALY rates and
SDIs for substance use disorders (rs=0·58, p=0·0012) and
skin and subcutaneous diseases (rs=0·45, p=0·017), whereas
negative correlations were found between DALY rates and SDIs
for cardiovascular diseases (rs=-0·46, p=0·015), neoplasms
(rs=-0·57, p=0·0015), and sense organ diseases (rs=-0·61,
p=0·0005).NCD-related mortality has substantially declined
among adolescents in the EU between 1990 and 2019, but the
rising trend of YLL attributed to mental disorders and their
YLD burden are concerning. Differences by sex, age group,
and across EU Member States highlight the importance of
preventive interventions and scaling up
adolescent-responsive health-care systems, which should
prioritise specific needs by sex, age, and location.Bill
$\&$ Melinda Gates Foundation.},
keywords = {Adolescent / Disabled Persons / Female / Global Burden of
Disease / Humans / Life Expectancy / Male / Noncommunicable
Diseases: epidemiology / Risk Factors},
cin = {C070 / C120},
ddc = {610},
cid = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35339209},
pmc = {pmc:PMC9090900},
doi = {10.1016/S2352-4642(22)00073-6},
url = {https://inrepo02.dkfz.de/record/182614},
}
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