000182619 001__ 182619 000182619 005__ 20240229145725.0 000182619 0247_ $$2doi$$a10.1016/S2542-5196(22)00122-X 000182619 0247_ $$2pmid$$apmid:35809588 000182619 0247_ $$2pmc$$apmc:PMC9278144 000182619 0247_ $$2altmetric$$aaltmetric:130766449 000182619 037__ $$aDKFZ-2022-02796 000182619 041__ $$aEnglish 000182619 082__ $$a000 000182619 1001_ $$aDiabetes, GBD 2019$$b0 000182619 245__ $$aEstimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2·5 air pollution, 1990-2019: an analysis of data from the Global Burden of Disease Study 2019. 000182619 260__ $$aAmsterdam$$bElsevier$$c2022 000182619 3367_ $$2DRIVER$$aarticle 000182619 3367_ $$2DataCite$$aOutput Types/Journal article 000182619 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1671708325_16329 000182619 3367_ $$2BibTeX$$aARTICLE 000182619 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000182619 3367_ $$00$$2EndNote$$aJournal Article 000182619 500__ $$aThe Lancet. Planetary health / ISSN:2542-5196 (Electronic) / 2542-5196 (Linking) 000182619 520__ $$aExperimental and epidemiological studies indicate an association between exposure to particulate matter (PM) air pollution and increased risk of type 2 diabetes. In view of the high and increasing prevalence of diabetes, we aimed to quantify the burden of type 2 diabetes attributable to PM2·5 originating from ambient and household air pollution.We systematically compiled all relevant cohort and case-control studies assessing the effect of exposure to household and ambient fine particulate matter (PM2·5) air pollution on type 2 diabetes incidence and mortality. We derived an exposure-response curve from the extracted relative risk estimates using the MR-BRT (meta-regression-Bayesian, regularised, trimmed) tool. The estimated curve was linked to ambient and household PM2·5 exposures from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, and estimates of the attributable burden (population attributable fractions and rates per 100 000 population of deaths and disability-adjusted life-years) for 204 countries from 1990 to 2019 were calculated. We also assessed the role of changes in exposure, population size, age, and type 2 diabetes incidence in the observed trend in PM2·5-attributable type 2 diabetes burden. All estimates are presented with 95% uncertainty intervals.In 2019, approximately a fifth of the global burden of type 2 diabetes was attributable to PM2·5 exposure, with an estimated 3·78 (95% uncertainty interval 2·68-4·83) deaths per 100 000 population and 167 (117-223) disability-adjusted life-years (DALYs) per 100 000 population. Approximately 13·4% (9·49-17·5) of deaths and 13·6% (9·73-17·9) of DALYs due to type 2 diabetes were contributed by ambient PM2·5, and 6·50% (4·22-9·53) of deaths and 5·92% (3·81-8·64) of DALYs by household air pollution. High burdens, in terms of numbers as well as rates, were estimated in Asia, sub-Saharan Africa, and South America. Since 1990, the attributable burden has increased by 50%, driven largely by population growth and ageing. Globally, the impact of reductions in household air pollution was largely offset by increased ambient PM2·5.Air pollution is a major risk factor for diabetes. We estimated that about a fifth of the global burden of type 2 diabetes is attributable PM2·5 pollution. Air pollution mitigation therefore might have an essential role in reducing the global disease burden resulting from type 2 diabetes.Bill & Melinda Gates Foundation. 000182619 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0 000182619 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de 000182619 650_7 $$2NLM Chemicals$$aParticulate Matter 000182619 650_2 $$2MeSH$$aAir Pollution: adverse effects 000182619 650_2 $$2MeSH$$aBayes Theorem 000182619 650_2 $$2MeSH$$aDiabetes Mellitus, Type 2: chemically induced 000182619 650_2 $$2MeSH$$aDiabetes Mellitus, Type 2: epidemiology 000182619 650_2 $$2MeSH$$aGlobal Burden of Disease 000182619 650_2 $$2MeSH$$aHumans 000182619 650_2 $$2MeSH$$aParticulate Matter: adverse effects 000182619 650_2 $$2MeSH$$aQuality-Adjusted Life Years 000182619 7001_ $$aAir Pollution Collaborators$$b1$$eCollaboration Author 000182619 7001_ $$aBurkart, Katrin$$b2$$eContributor 000182619 7001_ 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