%0 Journal Article
%A Eyl-Armbruster, Ruth Elisa
%A Thong, Melissa
%A Carr, Prudence
%A Jansen, Lina
%A Chang-Claude, Jenny
%A Hoffmeister, Michael
%A Brenner, Hermann
%A Arndt, Volker
%T Change Toward Healthier Lifestyles Is Associated With Better Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors.
%J Journal of the National Comprehensive Cancer Network
%V 20
%N 11
%@ 1540-1405
%C Cold Spring Harbor, NY
%I Harborside Press
%M DKFZ-2022-02798
%P 1233 - 1243.e10
%D 2022
%Z #EA:C070#EA:C071#LA:C071#
%X Little is known about how changes in a constellation of lifestyle factors affect health-related quality of life (HRQoL) in colorectal cancer (CRC) survivors. Our study aimed to investigate the association between changes in healthy lifestyle and HRQoL over time in survivors of stage I-IV CRC.We included 2,283 long-term (≥5 years postdiagnosis) survivors. A healthy lifestyle score (HLS) comprising smoking, alcohol consumption, diet, physical activity, and body fatness was derived at diagnosis and 5-year follow-up (5YFU) and categorized as low, moderate, or high. We assessed HRQoL with the EORTC Quality of Life Questionnaire-Core 30 at 5YFU and 10-year follow-up. We used multivariable linear regression and linear mixed models to explore associations between changes in HLS and HRQoL over follow-up.A low baseline HLS was associated with poorer functioning and global health/QoL and a higher symptom burden at 5YFU compared with a high baseline HLS. An improved HLS from baseline to 5YFU was associated with better functioning, higher global health/QoL, and fewer symptoms at 5YFU than a maintained-high HLS. In longitudinal analyses, improved HLS was associated with better functioning at follow-up. Survivors with a maintained-high or an improved HLS reported generally less fatigue, pain, and dyspnea at follow-ups compared with survivors with a maintained-low or decreased HLS.Change toward a healthier lifestyle since diagnosis was associated with better HRQoL in long-term CRC survivors. Our results support the importance of maintaining and/or promoting a healthier lifestyle among CRC survivors postdiagnosis.
%K Humans
%K Quality of Life
%K Healthy Lifestyle
%K Life Style
%K Survivors
%K Colorectal Neoplasms: complications
%K Surveys and Questionnaires
%K Colorectal Cancer (Other)
%K healthy lifestyle (Other)
%K long-term survivors (Other)
%K longitudinal (Other)
%K quality of life (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36351340
%R 10.6004/jnccn.2022.7049
%U https://inrepo02.dkfz.de/record/182621