TY  - JOUR
AU  - Eyl-Armbruster, Ruth Elisa
AU  - Thong, Melissa
AU  - Carr, Prudence
AU  - Jansen, Lina
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
AU  - Arndt, Volker
TI  - Change Toward Healthier Lifestyles Is Associated With Better Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors.
JO  - Journal of the National Comprehensive Cancer Network
VL  - 20
IS  - 11
SN  - 1540-1405
CY  - Cold Spring Harbor, NY
PB  - Harborside Press
M1  - DKFZ-2022-02798
SP  - 1233 - 1243.e10
PY  - 2022
N1  - #EA:C070#EA:C071#LA:C071#
AB  - Little is known about how changes in a constellation of lifestyle factors affect health-related quality of life (HRQoL) in colorectal cancer (CRC) survivors. Our study aimed to investigate the association between changes in healthy lifestyle and HRQoL over time in survivors of stage I-IV CRC.We included 2,283 long-term (≥5 years postdiagnosis) survivors. A healthy lifestyle score (HLS) comprising smoking, alcohol consumption, diet, physical activity, and body fatness was derived at diagnosis and 5-year follow-up (5YFU) and categorized as low, moderate, or high. We assessed HRQoL with the EORTC Quality of Life Questionnaire-Core 30 at 5YFU and 10-year follow-up. We used multivariable linear regression and linear mixed models to explore associations between changes in HLS and HRQoL over follow-up.A low baseline HLS was associated with poorer functioning and global health/QoL and a higher symptom burden at 5YFU compared with a high baseline HLS. An improved HLS from baseline to 5YFU was associated with better functioning, higher global health/QoL, and fewer symptoms at 5YFU than a maintained-high HLS. In longitudinal analyses, improved HLS was associated with better functioning at follow-up. Survivors with a maintained-high or an improved HLS reported generally less fatigue, pain, and dyspnea at follow-ups compared with survivors with a maintained-low or decreased HLS.Change toward a healthier lifestyle since diagnosis was associated with better HRQoL in long-term CRC survivors. Our results support the importance of maintaining and/or promoting a healthier lifestyle among CRC survivors postdiagnosis.
KW  - Humans
KW  - Quality of Life
KW  - Healthy Lifestyle
KW  - Life Style
KW  - Survivors
KW  - Colorectal Neoplasms: complications
KW  - Surveys and Questionnaires
KW  - Colorectal Cancer (Other)
KW  - healthy lifestyle (Other)
KW  - long-term survivors (Other)
KW  - longitudinal (Other)
KW  - quality of life (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36351340
DO  - DOI:10.6004/jnccn.2022.7049
UR  - https://inrepo02.dkfz.de/record/182621
ER  -