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@ARTICLE{EylArmbruster:182621,
      author       = {R. E. Eyl-Armbruster$^*$ and M. Thong$^*$ and P. Carr$^*$
                      and L. Jansen$^*$ and J. Chang-Claude$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$ and V. Arndt$^*$},
      title        = {{C}hange {T}oward {H}ealthier {L}ifestyles {I}s
                      {A}ssociated {W}ith {B}etter {H}ealth-{R}elated {Q}uality of
                      {L}ife in {L}ong-{T}erm {C}olorectal {C}ancer {S}urvivors.},
      journal      = {Journal of the National Comprehensive Cancer Network},
      volume       = {20},
      number       = {11},
      issn         = {1540-1405},
      address      = {Cold Spring Harbor, NY},
      publisher    = {Harborside Press},
      reportid     = {DKFZ-2022-02798},
      pages        = {1233 - 1243.e10},
      year         = {2022},
      note         = {#EA:C070#EA:C071#LA:C071#},
      abstract     = {Little is known about how changes in a constellation of
                      lifestyle factors affect health-related quality of life
                      (HRQoL) in colorectal cancer (CRC) survivors. Our study
                      aimed to investigate the association between changes in
                      healthy lifestyle and HRQoL over time in survivors of stage
                      I-IV CRC.We included 2,283 long-term (≥5 years
                      postdiagnosis) survivors. A healthy lifestyle score (HLS)
                      comprising smoking, alcohol consumption, diet, physical
                      activity, and body fatness was derived at diagnosis and
                      5-year follow-up (5YFU) and categorized as low, moderate, or
                      high. We assessed HRQoL with the EORTC Quality of Life
                      Questionnaire-Core 30 at 5YFU and 10-year follow-up. We used
                      multivariable linear regression and linear mixed models to
                      explore associations between changes in HLS and HRQoL over
                      follow-up.A low baseline HLS was associated with poorer
                      functioning and global health/QoL and a higher symptom
                      burden at 5YFU compared with a high baseline HLS. An
                      improved HLS from baseline to 5YFU was associated with
                      better functioning, higher global health/QoL, and fewer
                      symptoms at 5YFU than a maintained-high HLS. In longitudinal
                      analyses, improved HLS was associated with better
                      functioning at follow-up. Survivors with a maintained-high
                      or an improved HLS reported generally less fatigue, pain,
                      and dyspnea at follow-ups compared with survivors with a
                      maintained-low or decreased HLS.Change toward a healthier
                      lifestyle since diagnosis was associated with better HRQoL
                      in long-term CRC survivors. Our results support the
                      importance of maintaining and/or promoting a healthier
                      lifestyle among CRC survivors postdiagnosis.},
      keywords     = {Humans / Quality of Life / Healthy Lifestyle / Life Style /
                      Survivors / Colorectal Neoplasms: complications / Surveys
                      and Questionnaires / Colorectal Cancer (Other) / healthy
                      lifestyle (Other) / long-term survivors (Other) /
                      longitudinal (Other) / quality of life (Other)},
      cin          = {C070 / C071 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C071-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36351340},
      doi          = {10.6004/jnccn.2022.7049},
      url          = {https://inrepo02.dkfz.de/record/182621},
}