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024 7 _ |a 10.6004/jnccn.2022.7049
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037 _ _ |a DKFZ-2022-02798
041 _ _ |a English
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100 1 _ |a Eyl-Armbruster, Ruth Elisa
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245 _ _ |a Change Toward Healthier Lifestyles Is Associated With Better Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors.
260 _ _ |a Cold Spring Harbor, NY
|c 2022
|b Harborside Press
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520 _ _ |a Little is known about how changes in a constellation of lifestyle factors affect health-related quality of life (HRQoL) in colorectal cancer (CRC) survivors. Our study aimed to investigate the association between changes in healthy lifestyle and HRQoL over time in survivors of stage I-IV CRC.We included 2,283 long-term (≥5 years postdiagnosis) survivors. A healthy lifestyle score (HLS) comprising smoking, alcohol consumption, diet, physical activity, and body fatness was derived at diagnosis and 5-year follow-up (5YFU) and categorized as low, moderate, or high. We assessed HRQoL with the EORTC Quality of Life Questionnaire-Core 30 at 5YFU and 10-year follow-up. We used multivariable linear regression and linear mixed models to explore associations between changes in HLS and HRQoL over follow-up.A low baseline HLS was associated with poorer functioning and global health/QoL and a higher symptom burden at 5YFU compared with a high baseline HLS. An improved HLS from baseline to 5YFU was associated with better functioning, higher global health/QoL, and fewer symptoms at 5YFU than a maintained-high HLS. In longitudinal analyses, improved HLS was associated with better functioning at follow-up. Survivors with a maintained-high or an improved HLS reported generally less fatigue, pain, and dyspnea at follow-ups compared with survivors with a maintained-low or decreased HLS.Change toward a healthier lifestyle since diagnosis was associated with better HRQoL in long-term CRC survivors. Our results support the importance of maintaining and/or promoting a healthier lifestyle among CRC survivors postdiagnosis.
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650 _ 7 |a Colorectal Cancer
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650 _ 7 |a healthy lifestyle
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650 _ 7 |a long-term survivors
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650 _ 7 |a longitudinal
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650 _ 7 |a quality of life
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Quality of Life
|2 MeSH
650 _ 2 |a Healthy Lifestyle
|2 MeSH
650 _ 2 |a Life Style
|2 MeSH
650 _ 2 |a Survivors
|2 MeSH
650 _ 2 |a Colorectal Neoplasms: complications
|2 MeSH
650 _ 2 |a Surveys and Questionnaires
|2 MeSH
700 1 _ |a Thong, Melissa
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700 1 _ |a Carr, Prudence
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700 1 _ |a Jansen, Lina
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700 1 _ |a Chang-Claude, Jenny
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700 1 _ |a Hoffmeister, Michael
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700 1 _ |a Brenner, Hermann
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700 1 _ |a Arndt, Volker
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773 _ _ |a 10.6004/jnccn.2022.7049
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