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000182682 0247_ $$2doi$$a10.1016/j.jbc.2022.102703
000182682 0247_ $$2pmid$$apmid:36395886
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000182682 0247_ $$2ISSN$$a1083-351X
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000182682 037__ $$aDKFZ-2022-02850
000182682 041__ $$aEnglish
000182682 082__ $$a540
000182682 1001_ $$0P:(DE-He78)d4c68225ca6cd393718be733a8e4097d$$aHänle-Kreidler, Simon$$b0$$eFirst author$$udkfz
000182682 245__ $$aThe SCF-FBXW7 E3 ubiquitin ligase triggers degradation of Histone 3 Lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.
000182682 260__ $$aBethesda, Md.$$bSoc.$$c2022
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000182682 520__ $$aDuring prolonged mitotic arrest induced by anti-microtubule drugs, cell fate decision is determined by two alternative pathways, one leading to cell death, the other inducing premature escape from mitosis by mitotic slippage. FBWX7, a member of the F-box family of proteins and substrate-targeting subunit of the SCF (SKP1-CUL1-F-Box) E3 ubiquitin ligase complex promotes mitotic cell death and prevents mitotic slippage, but molecular details underlying these roles for FBWX7 are unclear. In this study, we report that WDR5, a component of the mixed lineage leukemia (MLL) complex of Histone 3 Lysine 4 (H3K4) methyltransferases, is a substrate of FBXW7. We determined by co-immunoprecipitation experiments and in vitro binding assays that WDR5 interacts with FBXW7 in vivo and in vitro. SCF-FBXW7 mediates ubiquitination of WDR5 and targets it for proteasomal degradation. Furthermore, we find that WDR5 depletion counteracts FBXW7 loss-of-function by reducing mitotic slippage and polyploidization. In conclusion, our data elucidate a new mechanism in mitotic cell fate regulation which might contribute to prevent chemotherapy resistance in patients after anti-microtubule drug treatment.
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000182682 650_7 $$2Other$$aFBXW7
000182682 650_7 $$2Other$$aWDR5
000182682 650_7 $$2Other$$achemoresistance
000182682 650_7 $$2Other$$amitotic slippage
000182682 650_7 $$2Other$$aubiquitylation (ubiquitination)
000182682 7001_ $$0P:(DE-He78)f08cb94a1ca44e0f65e828ea1c2edca4$$aRichter, Kai$$b1
000182682 7001_ $$0P:(DE-He78)b97fa0c782a162d952b6197f3b916379$$aHoffmann, Ingrid$$b2$$eLast author$$udkfz
000182682 773__ $$0PERI:(DE-600)1474604-9$$a10.1016/j.jbc.2022.102703$$gp. 102703 -$$n12$$p102703$$tThe journal of biological chemistry$$v298$$x0021-9258$$y2022
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000182682 9141_ $$y2022
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