%0 Journal Article
%A Schneider, Sergej
%A Stefanowicz, Sarah
%A Jentsch, Christina
%A Lohaus, Fabian
%A Thiele, Julia
%A Haak, Danilo
%A Valentini, Chiara
%A Platzek, Ivan
%A G. C. Troost, Esther
%A Hoffmann, Aswin L.
%T Reduction of intrafraction pancreas motion using an abdominal corset compatible with proton therapy and MRI
%J Clinical and translational radiation oncology
%V 38
%@ 2405-6308
%C Amsterdam
%I Elsevier
%M DKFZ-2022-02869
%P 111 - 116
%D 2022
%X Background and purpose: Motion mitigation is of crucial importance in particle therapy (PT) of patients with abdominal tumors to ensure high-precision irradiation. Magnetic resonance imaging (MRI) is an excellent modality for target volume delineation and motion estimation of mobile soft-tissue tumors. Thus, the aims of this study were to develop an MRI- and PT-compatible abdominal compression device, to investigate its effect on pancreas motion reduction, and to evaluate patient tolerability and acceptance.Materials and methods: In a prospective clinical study, 16 patients with abdominal tumors received an individualized polyethylene-based abdominal corset. Pancreas motion was analyzed using time- and phase resolved MRI scans (orthogonal 2D-cine and 4D MRI) with and without compression by the corset. The pancreas was manually segmented in each MRI data set and the population-averaged center-of-mass motion in inferior-superior (IS), anterior-posterior (AP) and left-right (LR) directions was determined. A questionnaire was developed to investigate the level of patient acceptance of the corset, which the patients completed after acquisition of the planning computed tomography (CT) and MRI scans.Results: The corset was found to reduce pancreas motion predominantly in IS direction by on average 47 
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1016/j.ctro.2022.11.006
%U https://inrepo02.dkfz.de/record/182711