TY  - JOUR
AU  - Schneider, Sergej
AU  - Stefanowicz, Sarah
AU  - Jentsch, Christina
AU  - Lohaus, Fabian
AU  - Thiele, Julia
AU  - Haak, Danilo
AU  - Valentini, Chiara
AU  - Platzek, Ivan
AU  - G. C. Troost, Esther
AU  - Hoffmann, Aswin L.
TI  - Reduction of intrafraction pancreas motion using an abdominal corset compatible with proton therapy and MRI
JO  - Clinical and translational radiation oncology
VL  - 38
SN  - 2405-6308
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2022-02869
SP  - 111 - 116
PY  - 2022
AB  - Background and purpose: Motion mitigation is of crucial importance in particle therapy (PT) of patients with abdominal tumors to ensure high-precision irradiation. Magnetic resonance imaging (MRI) is an excellent modality for target volume delineation and motion estimation of mobile soft-tissue tumors. Thus, the aims of this study were to develop an MRI- and PT-compatible abdominal compression device, to investigate its effect on pancreas motion reduction, and to evaluate patient tolerability and acceptance.Materials and methods: In a prospective clinical study, 16 patients with abdominal tumors received an individualized polyethylene-based abdominal corset. Pancreas motion was analyzed using time- and phase resolved MRI scans (orthogonal 2D-cine and 4D MRI) with and without compression by the corset. The pancreas was manually segmented in each MRI data set and the population-averaged center-of-mass motion in inferior-superior (IS), anterior-posterior (AP) and left-right (LR) directions was determined. A questionnaire was developed to investigate the level of patient acceptance of the corset, which the patients completed after acquisition of the planning computed tomography (CT) and MRI scans.Results: The corset was found to reduce pancreas motion predominantly in IS direction by on average 47 
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1016/j.ctro.2022.11.006
UR  - https://inrepo02.dkfz.de/record/182711
ER  -