%0 Journal Article
%A Alwers, Elizabeth
%A Kather, Jakob N
%A Kloor, Matthias
%A Brobeil, Alexander
%A Tagscherer, Katrin E
%A Roth, Wilfried
%A Echle, Amelie
%A Amitay, Efrat
%A Chang-Claude, Jenny
%A Brenner, Hermann
%A Hoffmeister, Michael
%T Validation of the prognostic value of CD3 and CD8 cell densities analogous to the Immunoscore® by stage and location of colorectal cancer: an independent patient cohort study.
%J The journal of pathology: clinical research
%V 9
%N 2
%@ 2056-4538
%C Chichester
%I Wiley
%M DKFZ-2022-02903
%P 129-136
%D 2023
%Z #EA:C070#LA:C070# / 2023 Mar;9(2):129-136
%X In addition to the traditional staging system in colorectal cancer (CRC), the Immunoscore® has been proposed to characterize the level of immune infiltration in tumor tissue and as a potential prognostic marker. The aim of this study was to examine and validate associations of an immune cell score analogous to the Immunoscore® with established molecular tumor markers and with CRC patient survival in a routine setting. Patients from a population-based cohort study with available CRC tumor tissue blocks were included in this analysis. CD3+ and CD8+ tumor infiltrating lymphocytes in the tumor center and invasive margin were determined in stained tumor tissue slides. Based on the T-cell density in each region, an immune cell score closely analogous to the concept of the Immunoscore® was calculated and tumors categorized into IS-low, IS-intermediate, or IS-high. Logistic regression models were used to assess associations between clinicopathological characteristics with the immune cell score, and Cox proportional hazards models to analyze associations with cancer-specific, relapse-free, and overall survival. From 1,535 patients with CRC, 411 (27
%K colorectal cancer (Other)
%K immune infiltration (Other)
%K microsatellite instability (Other)
%K survival (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36424650
%R 10.1002/cjp2.304
%U https://inrepo02.dkfz.de/record/182763