TY  - JOUR
AU  - Alwers, Elizabeth
AU  - Kather, Jakob N
AU  - Kloor, Matthias
AU  - Brobeil, Alexander
AU  - Tagscherer, Katrin E
AU  - Roth, Wilfried
AU  - Echle, Amelie
AU  - Amitay, Efrat
AU  - Chang-Claude, Jenny
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
TI  - Validation of the prognostic value of CD3 and CD8 cell densities analogous to the Immunoscore® by stage and location of colorectal cancer: an independent patient cohort study.
JO  - The journal of pathology: clinical research
VL  - 9
IS  - 2
SN  - 2056-4538
CY  - Chichester
PB  - Wiley
M1  - DKFZ-2022-02903
SP  - 129-136
PY  - 2023
N1  - #EA:C070#LA:C070# / 2023 Mar;9(2):129-136
AB  - In addition to the traditional staging system in colorectal cancer (CRC), the Immunoscore® has been proposed to characterize the level of immune infiltration in tumor tissue and as a potential prognostic marker. The aim of this study was to examine and validate associations of an immune cell score analogous to the Immunoscore® with established molecular tumor markers and with CRC patient survival in a routine setting. Patients from a population-based cohort study with available CRC tumor tissue blocks were included in this analysis. CD3+ and CD8+ tumor infiltrating lymphocytes in the tumor center and invasive margin were determined in stained tumor tissue slides. Based on the T-cell density in each region, an immune cell score closely analogous to the concept of the Immunoscore® was calculated and tumors categorized into IS-low, IS-intermediate, or IS-high. Logistic regression models were used to assess associations between clinicopathological characteristics with the immune cell score, and Cox proportional hazards models to analyze associations with cancer-specific, relapse-free, and overall survival. From 1,535 patients with CRC, 411 (27
KW  - colorectal cancer (Other)
KW  - immune infiltration (Other)
KW  - microsatellite instability (Other)
KW  - survival (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36424650
DO  - DOI:10.1002/cjp2.304
UR  - https://inrepo02.dkfz.de/record/182763
ER  -