Home > Publications database > Latent Membrane Protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma. > print

001     182766
005     20240229145730.0
024 7 _ |a 10.1002/path.6036
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024 7 _ |a 0368-3494
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024 7 _ |a 1096-9896
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024 7 _ |a 1555-2039
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037 _ _ |a DKFZ-2022-02906
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082 _ _ |a 610
100 1 _ |a Tang, Wing Chung
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245 _ _ |a Latent Membrane Protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma.
260 _ _ |a Bognor Regis [u.a.]
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500 _ _ |a 2023 Feb;259(2):163-179
520 _ _ |a Invadopodia are actin-rich membrane protrusions that digest the matrix barrier during cancer metastasis. Since the discovery of invadopodia, they were visualized as localized and dot-like structures in different types of cancer cells on top of a 2D matrix. In this investigation of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC), a highly invasive cancer frequently accompanied by neck lymph node and distal organ metastases, we revealed a new form of invadopodium with mobilizing features. Integration of live-cell imaging and molecular assays revealed the interaction of macrophage-released TNFα and EBV-encoded latent membrane protein 1 (LMP1) in co-activating the EGFR/Src/ERK/cortactin and Cdc42/N-WASP signaling axes for mobilizing the invadopodia with lateral movements. This phenomenon endows the invadopodia with massive degradative power, visualized as a shift of focal dot-like digestion patterns on a 2D gelatin to a dendrite-like digestion pattern. Notably, single stimulation of either LMP1 or TNFα could only enhance the number of ordinary dot-like invadopodia, suggesting that the EBV infection sensitizes the NPC cells to form mobilizing invadopodia when encountering a TNFα-rich tumor microenvironment. This study unveils the interplay of EBV and stromal components in driving the invasive potential of NPC via unleashing the propulsion of invadopodia in overcoming matrix hurdles. This article is protected by copyright. All rights reserved.
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650 _ 7 |a Epstein-Barr virus infection
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650 _ 7 |a invadopodia
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650 _ 7 |a invasion
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650 _ 7 |a latent membrane protein 1
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650 _ 7 |a live-cell imaging
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650 _ 7 |a nasopharyngeal carcinoma
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650 _ 7 |a tumor-associated macrophage
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700 1 _ |a Tsao, Sai Wah
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700 1 _ |a Jones, Gareth E
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700 1 _ |a Liu, Xiong
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700 1 _ |a Tsai, Ming Han
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700 1 _ |a Delecluse, Henri-Jacques
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700 1 _ |a Dai, Wei
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700 1 _ |a You, Chanping
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700 1 _ |a Zhang, Jun
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700 1 _ |a Huang, Shaina Chor Mei
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700 1 _ |a Leung, Manton Man-Hon
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700 1 _ |a Liu, Tengfei
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700 1 _ |a Ching, Yick Pang
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700 1 _ |a Chen, Honglin
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700 1 _ |a Lo, Kwok Wai
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700 1 _ |a Li, Xin
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700 1 _ |a Tsang, Chi Man
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