TY  - JOUR
AU  - Haehl, Erik
AU  - Alvino, Luisa
AU  - Rühle, Alexander
AU  - Zou, Jiadai
AU  - Fabian, Alexander
AU  - Grosu, Anca-Ligia
AU  - Nicolay, Nils H
TI  - Sarcopenia as a Prognostic Marker in Elderly Head and Neck Squamous Cell Carcinoma Patients Undergoing (Chemo-)Radiation.
JO  - Cancers
VL  - 14
IS  - 22
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-02927
SP  - 5536
PY  - 2022
N1  - #LA:E055#
AB  - Sarcopenia is associated with reduced survival and increased toxicity in malignant diseases. The prevalence of sarcopenia increases with age and is an important cause of functional decline. We analyzed sarcopenia and sarcopenia dynamics in elderly head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiation. Skeletal muscle mass of 280 elderly HNSCC-patients (>65 yrs) receiving curative (chemo)radiation was manually outlined and quantified on CT scans at the level of the C3 (C3MA). Cross-sectional muscle area at L3 (L3MA) was calculated and normalized to height (L3MI). Frequency distributions of clinical parameters as well as overall survival (OS), progression-free survival (PFS) and locoregional control (LRC) were calculated regarding sarcopenia. Calculated L3MA correlated with pretherapeutic hemoglobin-levels (ρ = 0.280) bodyweight (ρ = 0.702) and inversely with patient-age (ρ = -0.290). Sarcopenic patients featured larger tumors (T3/4 69.0
KW  - HNSCC (Other)
KW  - elderly (Other)
KW  - head-and-neck cancer (Other)
KW  - head-and-neck squamous cell carcinoma (Other)
KW  - radiotherapy (Other)
KW  - sarcopenia (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36428629
DO  - DOI:10.3390/cancers14225536
UR  - https://inrepo02.dkfz.de/record/182795
ER  -