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000182807 1001_ $$0P:(DE-HGF)0$$aJurmeister, Philipp$$b0
000182807 245__ $$aDNA methylation-based classification of sinonasal tumors.
000182807 260__ $$a[London]$$bNature Publishing Group UK$$c2022
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000182807 520__ $$aThe diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SNUCs). In this study, we apply a machine learning algorithm based on DNA methylation patterns to classify sinonasal tumors with clinical-grade reliability. We further show that sinonasal tumors with SNUC morphology are not as undifferentiated as their current terminology suggests but rather reassigned to four distinct molecular classes defined by epigenetic, mutational and proteomic profiles. This includes two classes with neuroendocrine differentiation, characterized by IDH2 or SMARCA4/ARID1A mutations with an overall favorable clinical course, one class composed of highly aggressive SMARCB1-deficient carcinomas and another class with tumors that represent potentially previously misclassified adenoid cystic carcinomas. Our findings can aid in improving the diagnostic classification of sinonasal tumors and could help to change the current perception of SNUCs.
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000182807 7001_ $$aGlöß, Stefanie$$b1
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000182807 7001_ $$aLeitheiser, Maximilian$$b3
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000182807 7001_ $$aMochmann, Liliana H$$b5
000182807 7001_ $$aPayá Capilla, Emma$$b6
000182807 7001_ $$aFritz, Rebecca$$b7
000182807 7001_ $$aDittmayer, Carsten$$b8
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000182807 7001_ $$aKeyl, Philipp$$b11
000182807 7001_ $$aJarosch, Armin$$b12
000182807 7001_ $$aSchallenberg, Simon$$b13
000182807 7001_ $$aBläker, Hendrik$$b14
000182807 7001_ $$aHoffmann, Inga$$b15
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000182807 7001_ $$aLehmann, Annika$$b17
000182807 7001_ $$0P:(DE-HGF)0$$aHummel, Michael$$b18
000182807 7001_ $$aHeim, Daniel$$b19
000182807 7001_ $$aHaji, Mohamed$$b20
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000182807 7001_ $$00000-0002-1769-5393$$aEnglert, Benjamin$$b22
000182807 7001_ $$aFrank, Stephan$$b23
000182807 7001_ $$aHench, Jürgen$$b24
000182807 7001_ $$aPaulus, Werner$$b25
000182807 7001_ $$aHasselblatt, Martin$$b26
000182807 7001_ $$00000-0002-7609-5021$$aHartmann, Wolfgang$$b27
000182807 7001_ $$aDohmen, Hildegard$$b28
000182807 7001_ $$00000-0002-0539-7065$$aKeber, Ursula$$b29
000182807 7001_ $$00000-0001-7076-0476$$aJank, Paul$$b30
000182807 7001_ $$00000-0002-2249-0982$$aDenkert, Carsten$$b31
000182807 7001_ $$00000-0003-1766-5458$$aStadelmann, Christine$$b32
000182807 7001_ $$aBremmer, Felix$$b33
000182807 7001_ $$aRichter, Annika$$b34
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000182807 7001_ $$aPerner, Sven$$b37
000182807 7001_ $$aIdel, Christian$$b38
000182807 7001_ $$aChiariotti, Lorenzo$$b39
000182807 7001_ $$aDella Monica, Rosa$$b40
000182807 7001_ $$aMarinelli, Alfredo$$b41
000182807 7001_ $$00000-0002-8731-1121$$aSchüller, Ulrich$$b42
000182807 7001_ $$aBockmayr, Michael$$b43
000182807 7001_ $$aLiu, Jacklyn$$b44
000182807 7001_ $$aLund, Valerie J$$b45
000182807 7001_ $$aForster, Martin$$b46
000182807 7001_ $$00000-0002-7123-0773$$aLechner, Matt$$b47
000182807 7001_ $$aLorenzo-Guerra, Sara L$$b48
000182807 7001_ $$00000-0002-5959-6289$$aHermsen, Mario$$b49
000182807 7001_ $$aJohann, Pascal D$$b50
000182807 7001_ $$00000-0002-0445-8161$$aAgaimy, Abbas$$b51
000182807 7001_ $$00000-0002-4707-7991$$aSeegerer, Philipp$$b52
000182807 7001_ $$aKoch, Arend$$b53
000182807 7001_ $$00000-0001-9816-8917$$aHeppner, Frank$$b54
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000182807 7001_ $$aSill, Martin$$b57
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000182807 7001_ $$aSnuderl, Matija$$b59
000182807 7001_ $$aMüller, Klaus-Robert$$b60
000182807 7001_ $$aForgó, Erna$$b61
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