guest ::
| Home > Publications database > DNA methylation-based classification of sinonasal tumors. > print |
| 001 | 182807 | ||
| 005 | 20240229145731.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-022-34815-3 |2 doi |
| 024 | 7 | _ | |a pmid:36443295 |2 pmid |
| 024 | 7 | _ | |a altmetric:139038617 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2022-02939 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Jurmeister, Philipp |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a DNA methylation-based classification of sinonasal tumors. |
| 260 | _ | _ | |a [London] |c 2022 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1669796807_18877 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SNUCs). In this study, we apply a machine learning algorithm based on DNA methylation patterns to classify sinonasal tumors with clinical-grade reliability. We further show that sinonasal tumors with SNUC morphology are not as undifferentiated as their current terminology suggests but rather reassigned to four distinct molecular classes defined by epigenetic, mutational and proteomic profiles. This includes two classes with neuroendocrine differentiation, characterized by IDH2 or SMARCA4/ARID1A mutations with an overall favorable clinical course, one class composed of highly aggressive SMARCB1-deficient carcinomas and another class with tumors that represent potentially previously misclassified adenoid cystic carcinomas. Our findings can aid in improving the diagnostic classification of sinonasal tumors and could help to change the current perception of SNUCs. |
| 536 | _ | _ | |a 312 - Funktionelle und strukturelle Genomforschung (POF4-312) |0 G:(DE-HGF)POF4-312 |c POF4-312 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 700 | 1 | _ | |a Glöß, Stefanie |b 1 |
| 700 | 1 | _ | |a Roller, Renée Fabienne |0 P:(DE-He78)213012d0f737dec4c4f4e1e61a02d74c |b 2 |
| 700 | 1 | _ | |a Leitheiser, Maximilian |b 3 |
| 700 | 1 | _ | |a Schmid, Simone |0 P:(DE-He78)6e4a8cc4eb35e694f95453ed8a927a83 |b 4 |u dkfz |
| 700 | 1 | _ | |a Mochmann, Liliana H |b 5 |
| 700 | 1 | _ | |a Payá Capilla, Emma |b 6 |
| 700 | 1 | _ | |a Fritz, Rebecca |b 7 |
| 700 | 1 | _ | |a Dittmayer, Carsten |b 8 |
| 700 | 1 | _ | |a Friedrich, Corinna |0 P:(DE-He78)9c8b1020fb1925f5bc504b9e77769844 |b 9 |u dkfz |
| 700 | 1 | _ | |a Thieme, Anne |0 P:(DE-He78)21f693ba604e9286be3b25068b440d08 |b 10 |u dkfz |
| 700 | 1 | _ | |a Keyl, Philipp |b 11 |
| 700 | 1 | _ | |a Jarosch, Armin |b 12 |
| 700 | 1 | _ | |a Schallenberg, Simon |b 13 |
| 700 | 1 | _ | |a Bläker, Hendrik |b 14 |
| 700 | 1 | _ | |a Hoffmann, Inga |b 15 |
| 700 | 1 | _ | |a Vollbrecht, Claudia |0 P:(DE-He78)ed973559beda9f54611a06471ba06776 |b 16 |
| 700 | 1 | _ | |a Lehmann, Annika |b 17 |
| 700 | 1 | _ | |a Hummel, Michael |0 P:(DE-HGF)0 |b 18 |
| 700 | 1 | _ | |a Heim, Daniel |b 19 |
| 700 | 1 | _ | |a Haji, Mohamed |b 20 |
| 700 | 1 | _ | |a Harter, Patrick |0 P:(DE-He78)b15b56a6ed37417d476470c60c0140ff |b 21 |
| 700 | 1 | _ | |a Englert, Benjamin |0 0000-0002-1769-5393 |b 22 |
| 700 | 1 | _ | |a Frank, Stephan |b 23 |
| 700 | 1 | _ | |a Hench, Jürgen |b 24 |
| 700 | 1 | _ | |a Paulus, Werner |b 25 |
| 700 | 1 | _ | |a Hasselblatt, Martin |b 26 |
| 700 | 1 | _ | |a Hartmann, Wolfgang |0 0000-0002-7609-5021 |b 27 |
| 700 | 1 | _ | |a Dohmen, Hildegard |b 28 |
| 700 | 1 | _ | |a Keber, Ursula |0 0000-0002-0539-7065 |b 29 |
| 700 | 1 | _ | |a Jank, Paul |0 0000-0001-7076-0476 |b 30 |
| 700 | 1 | _ | |a Denkert, Carsten |0 0000-0002-2249-0982 |b 31 |
| 700 | 1 | _ | |a Stadelmann, Christine |0 0000-0003-1766-5458 |b 32 |
| 700 | 1 | _ | |a Bremmer, Felix |b 33 |
| 700 | 1 | _ | |a Richter, Annika |b 34 |
| 700 | 1 | _ | |a Wefers, Annika |0 P:(DE-He78)32977c5abc127b0373ece54294a41f63 |b 35 |
| 700 | 1 | _ | |a Ribbat-Idel, Julika |b 36 |
| 700 | 1 | _ | |a Perner, Sven |b 37 |
| 700 | 1 | _ | |a Idel, Christian |b 38 |
| 700 | 1 | _ | |a Chiariotti, Lorenzo |b 39 |
| 700 | 1 | _ | |a Della Monica, Rosa |b 40 |
| 700 | 1 | _ | |a Marinelli, Alfredo |b 41 |
| 700 | 1 | _ | |a Schüller, Ulrich |0 0000-0002-8731-1121 |b 42 |
| 700 | 1 | _ | |a Bockmayr, Michael |b 43 |
| 700 | 1 | _ | |a Liu, Jacklyn |b 44 |
| 700 | 1 | _ | |a Lund, Valerie J |b 45 |
| 700 | 1 | _ | |a Forster, Martin |b 46 |
| 700 | 1 | _ | |a Lechner, Matt |0 0000-0002-7123-0773 |b 47 |
| 700 | 1 | _ | |a Lorenzo-Guerra, Sara L |b 48 |
| 700 | 1 | _ | |a Hermsen, Mario |0 0000-0002-5959-6289 |b 49 |
| 700 | 1 | _ | |a Johann, Pascal D |b 50 |
| 700 | 1 | _ | |a Agaimy, Abbas |0 0000-0002-0445-8161 |b 51 |
| 700 | 1 | _ | |a Seegerer, Philipp |0 0000-0002-4707-7991 |b 52 |
| 700 | 1 | _ | |a Koch, Arend |b 53 |
| 700 | 1 | _ | |a Heppner, Frank |0 0000-0001-9816-8917 |b 54 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 55 |u dkfz |
| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 56 |u dkfz |
| 700 | 1 | _ | |a Sill, Martin |b 57 |
| 700 | 1 | _ | |a von Deimling, Andreas |0 P:(DE-He78)a8a10626a848d31e70cfd96a133cc144 |b 58 |u dkfz |
| 700 | 1 | _ | |a Snuderl, Matija |b 59 |
| 700 | 1 | _ | |a Müller, Klaus-Robert |b 60 |
| 700 | 1 | _ | |a Forgó, Erna |b 61 |
| 700 | 1 | _ | |a Howitt, Brooke E |0 0000-0002-0309-6680 |b 62 |
| 700 | 1 | _ | |a Mertins, Philipp |0 0000-0002-2245-528X |b 63 |
| 700 | 1 | _ | |a Klauschen, Frederick |0 P:(DE-HGF)0 |b 64 |
| 700 | 1 | _ | |a Capper, David |0 P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c |b 65 |u dkfz |
| 773 | _ | _ | |a 10.1038/s41467-022-34815-3 |g Vol. 13, no. 1, p. 7148 |0 PERI:(DE-600)2553671-0 |n 1 |p 7148 |t Nature Communications |v 13 |y 2022 |x 2041-1723 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:182807 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)213012d0f737dec4c4f4e1e61a02d74c |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-He78)6e4a8cc4eb35e694f95453ed8a927a83 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)9c8b1020fb1925f5bc504b9e77769844 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 10 |6 P:(DE-He78)21f693ba604e9286be3b25068b440d08 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 16 |6 P:(DE-He78)ed973559beda9f54611a06471ba06776 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 18 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 21 |6 P:(DE-He78)b15b56a6ed37417d476470c60c0140ff |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 35 |6 P:(DE-He78)32977c5abc127b0373ece54294a41f63 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 54 |6 0000-0001-9816-8917 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 55 |6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 56 |6 P:(DE-He78)551bb92841f634070997aa168d818492 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 58 |6 P:(DE-He78)a8a10626a848d31e70cfd96a133cc144 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 64 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 65 |6 P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-312 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Funktionelle und strukturelle Genomforschung |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |d 2021-02-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-02-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-02-02 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-02-02 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2021-02-02 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2021-02-02 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT COMMUN : 2021 |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2021-10-13T14:44:21Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2021-10-13T14:44:21Z |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Peer review |d 2021-10-13T14:44:21Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |d 2022-11-11 |
| 915 | _ | _ | |a IF >= 15 |0 StatID:(DE-HGF)9915 |2 StatID |b NAT COMMUN : 2021 |d 2022-11-11 |
| 920 | 1 | _ | |0 I:(DE-He78)BE01-20160331 |k BE01 |l DKTK BE zentral |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)MU01-20160331 |k MU01 |l DKTK MU LMU zentral |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)FM01-20160331 |k FM01 |l DKTK FM zentral |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)HD01-20160331 |k HD01 |l DKTK HD zentral |x 3 |
| 920 | 1 | _ | |0 I:(DE-He78)B300-20160331 |k B300 |l KKE Neuropathologie |x 4 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l B062 Pädiatrische Neuroonkologie |x 5 |
| 920 | 1 | _ | |0 I:(DE-He78)B360-20160331 |k B360 |l Pediatric Glioma |x 6 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)BE01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)MU01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)FM01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)HD01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B300-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B360-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|