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@ARTICLE{Heumann:182814,
      author       = {P. Heumann$^*$ and M. E. Aguado-Barrera and B. Avuzzi and
                      D. Azria and E. Briers and R. Bultijnck and A. Choudhury and
                      D. De Ruysscher and M.-P. Farcy-Jacquet and V. Fonteyne and
                      A. Gómez Caamaño and I. Helmbold$^*$ and K. Johnson and S.
                      L. Kerns and M. Lambrecht and Z. Lingard and T. Rancati and
                      B. Rosenstein and E. Sperk and R. Paul Symonds and C. Talbot
                      and R. Valdagni and A. Vega and L. Veldeman and T. Ward and
                      A. Webb and C. West and J. Chang-Claude$^*$ and P.
                      Seibold$^*$},
      collaboration = {R. Consortium},
      title        = {{C}omparing symptom reporting by prostate cancer patients
                      and healthcare professionals in the international
                      multicentre {REQUITE} study.},
      journal      = {Radiotherapy and oncology},
      volume       = {178},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2022-02946},
      pages        = {109426},
      year         = {2023},
      note         = {#EA:C020#LA:C020# / Volume 178, January 2023, 109426},
      abstract     = {Previous studies showed that healthcare professionals and
                      patients had only moderate to low agreement on their
                      assessment of treatment-related symptoms. We aimed to
                      determine the levels of agreement in a large cohort of
                      prostate cancer patients.Analyses were made of data from
                      1,756 prostate cancer patients treated with external beam
                      radiotherapy (RT) and/or brachytherapy in Europe and the USA
                      and recruited into the prospective multicentre observational
                      REQUITE study. Eleven pelvic symptoms at the end of RT were
                      compared after translating patient-reported outcomes (PROs)
                      into CTCAE-based healthcare professional ratings. Gwet's AC2
                      agreement coefficient and $95\%$ confidence intervals were
                      calculated for each symptom. To compare severity of grading
                      between patients and healthcare professionals, percent
                      agreement and deviations for each symptom were graphically
                      depicted. Stratified and sensitivity analyses were conducted
                      to identify potential influencing factors and to assess
                      heterogeneity and robustness of results.The agreement for
                      the 11 pelvic symptoms varied from very good (AC2>0.8:
                      haematuria, rectal bleeding, management of sphincter
                      control) to poor agreement (AC2≤0.2: urinary frequency
                      fair, proctitis and urinary urgency). Fatigue had a negative
                      impact on the agreement. Patients tended to grade symptoms
                      more severely than healthcare professionals. Information on
                      sexual dysfunction was missing more frequently in healthcare
                      professional assessment than PROs.Agreement was better for
                      observable than subjective symptoms, with patients usually
                      grading symptoms more severely than healthcare
                      professionals. Our findings emphasize that PROs should
                      complement symptom assessment by healthcare professionals
                      and be taken into consideration for clinical decision-making
                      to incorporate the patient perspective.},
      keywords     = {adverse events (Other) / agreement (Other) /
                      patient-reported outcomes (Other) / prostate cancer (Other)
                      / radiotherapy (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36442608},
      doi          = {10.1016/j.radonc.2022.11.015},
      url          = {https://inrepo02.dkfz.de/record/182814},
}