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@ARTICLE{Murphy:182833,
      author       = {N. Murphy and C. C. Newton and M. Song and N. Papadimitriou
                      and M. Hoffmeister$^*$ and A. I. Phipps and T. A. Harrison
                      and P. A. Newcomb and E. K. Aglago and S. I. Berndt and H.
                      Brenner$^*$ and D. D. Buchanan and Y. Cao and A. T. Chan and
                      X. Chen$^*$ and I. Cheng and J. Chang-Claude$^*$ and N.
                      Dimou and D. Drew and A. B. Farris and A. J. French and S.
                      Gallinger and P. Georgeson and M. Giannakis and G. G. Giles
                      and S. B. Gruber and S. Harlid and L. Hsu and W.-Y. Huang
                      and M. A. Jenkins and R. S. Laskar and L. Le Marchand and P.
                      Limburg and Y. Lin and M. Mandic$^*$ and J. A. Nowak and M.
                      Obón-Santacana and S. Ogino and C. Qu and L. C. Sakoda and
                      R. E. Schoen and M. C. Southey and Z. K. Stadler and R. S.
                      Steinfelder and W. Sun and S. N. Thibodeau and A. E. Toland
                      and Q. M. Trinh and K. K. Tsilidis and T. Ugai and B. Van
                      Guelpen and X. Wang and M. O. Woods and S. H. Zaidi and M.
                      J. Gunter and U. Peters and P. T. Campbell},
      title        = {{B}ody {M}ass {I}ndex and {M}olecular {S}ubtypes of
                      {C}olorectal {C}ancer.},
      journal      = {Journal of the National Cancer Institute},
      volume       = {115},
      number       = {2},
      issn         = {0027-8874},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2022-02960},
      pages        = {165-173},
      year         = {2023},
      note         = {2023 Feb 8;115(2):165-173},
      abstract     = {Obesity is an established risk factor for colorectal cancer
                      (CRC); but the evidence for the association is inconsistent
                      across molecular subtypes of the disease.We pooled data on
                      BMI, tumor microsatellite instability (MSI) status, CpG
                      island methylator phenotype (CIMP) status, BRAF and KRAS
                      mutations, and Jass classification types for 11,872 CRC
                      cases and 11,013 controls from 11 observational studies. We
                      used multinomial logistic regression to estimate odds ratio
                      (OR) and $95\%$ confidence intervals (CI) adjusted for
                      covariables.Higher BMI was associated with increased CRC
                      risk (OR per 5 kg/m2, 1.18, $95\%CI:$ 1.15-1.22). The
                      positive association was stronger for men than women, but
                      similar across tumor subtypes defined by individual
                      molecular markers. In analyses by Jass type, higher BMI was
                      associated with elevated CRC risk for types 1-4 cases but
                      not for type 5 CRC cases (considered familial-like/Lynch
                      syndrome MSI-H, CIMP-low/negative, BRAF-wildtype,
                      KRAS-wildtype, OR, 1.04, $95\%CI:$ 0.90-1.20). This pattern
                      of associations for BMI and Jass types was consistent by sex
                      and design of contributing studies (cohort or
                      case-control).In contrast to previous reports with fewer
                      study participants, we found limited evidence of
                      heterogeneity for the association between BMI and CRC risk
                      according to molecular subtype, suggesting that obesity
                      influences nearly all major pathways involved in colorectal
                      carcinogenesis. The null association observed for the Jass
                      type 5 suggests that BMI is not a risk factor for the
                      development of CRC for individuals with Lynch syndrome.},
      cin          = {C070 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36445035},
      doi          = {10.1093/jnci/djac215},
      url          = {https://inrepo02.dkfz.de/record/182833},
}