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000182870 041__ $$aEnglish
000182870 082__ $$a610
000182870 1001_ $$aHimbert, Caroline$$b0
000182870 245__ $$aDifferences in the gut microbiome by physical activity and BMI among colorectal cancer patients.
000182870 260__ $$aMadison, Wis.$$be-Century Publ.$$c2022
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000182870 500__ $$aAm J Cancer Res 2022;12(10):4789-4801www.ajcr.us /ISSN:2156-6976/ajcr0145332
000182870 520__ $$aAssociations of energy balance components, including physical activity and obesity, with colorectal cancer risk and mortality are well established. However, the gut microbiome has not been investigated as underlying mechanism. We investigated associations of physical activity, BMI, and combinations of physical activity/BMI with gut microbiome diversity and differential abundances among colorectal cancer patients. N=179 patients with colorectal cancer (stages I-IV) were included in the study. Pre-surgery stool samples were used to perform 16S rRNA gene sequencing (Illumina). Physical activity (MET hrs/wk) during the year before diagnosis was assessed by questionnaire and participants were classified as being active vs. inactive based on guidelines. BMI at baseline was abstracted from medical records. Patients were classified into four combinations of physical activity levels/BMI. Lower gut microbial diversity was observed among 'inactive' vs. 'active' patients (Shannon: P=0.01, Simpson: P=0.03), 'obese' vs. 'normal weight' patients (Shannon, Simpson, and Observed species: P=0.02, respectively), and 'overweight/obese/inactive' vs. 'normal weight/active' patients (Shannon: P=0.02, Observed species: P=0.04). Results differed by sex and tumor site. Two phyla and 12 genera (Actinobacteria and Fusobacteria, Adlercreutzia, Anaerococcus, Clostridium, Eubacterium, Mogibacteriaceae, Olsenella, Peptinophilus, Pyramidobacter, RFN20, Ruminococcus, Succinivibrio, Succiniclasticum) were differentially abundant across physical activity and BMI groups. This is the first evidence for associations of physical activity with gut microbiome diversity and abundances, directly among colorectal cancer patients. Our results indicate that physical activity may offset gut microbiome dysbiosis due to obesity. Alterations in gut microbiota may contribute mechanistically to the energy balance-colorectal cancer link and impact clinical outcomes.
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000182870 650_7 $$2Other$$aColorectal cancer
000182870 650_7 $$2Other$$aenergy balance
000182870 650_7 $$2Other$$amicrobiome
000182870 650_7 $$2Other$$aobesity
000182870 650_7 $$2Other$$aphysical activity
000182870 7001_ $$aStephens, W Zac$$b1
000182870 7001_ $$aGigic, Biljana$$b2
000182870 7001_ $$aHardikar, Sheetal$$b3
000182870 7001_ $$aHolowatyj, Andreana N$$b4
000182870 7001_ $$aLin, Tengda$$b5
000182870 7001_ $$aOse, Jennifer$$b6
000182870 7001_ $$aSwanson, Eric$$b7
000182870 7001_ $$aAshworth, Anjelica$$b8
000182870 7001_ $$aWarby, Christy A$$b9
000182870 7001_ $$aPeoples, Anita R$$b10
000182870 7001_ $$aNix, David$$b11
000182870 7001_ $$aJedrzkiewicz, Jolanta$$b12
000182870 7001_ $$aBronner, Mary$$b13
000182870 7001_ $$aPickron, Bartley$$b14
000182870 7001_ $$aScaife, Courtney$$b15
000182870 7001_ $$aCohan, Jessica N$$b16
000182870 7001_ $$0P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aSchrotz-King, Petra$$b17$$udkfz
000182870 7001_ $$aHabermann, Nina$$b18
000182870 7001_ $$aBoehm, Juergen$$b19
000182870 7001_ $$aHullar, Meredith$$b20
000182870 7001_ $$aFigueiredo, Jane C$$b21
000182870 7001_ $$aToriola, Adetunji T$$b22
000182870 7001_ $$aSiegel, Erin M$$b23
000182870 7001_ $$aLi, Christopher I$$b24
000182870 7001_ $$aUlrich, Alexis B$$b25
000182870 7001_ $$aShibata, David$$b26
000182870 7001_ $$aBoucher, Kenneth$$b27
000182870 7001_ $$aHuang, Lyen C$$b28
000182870 7001_ $$aSchneider, Martin$$b29
000182870 7001_ $$aRound, June L$$b30
000182870 7001_ $$aUlrich, Cornelia M$$b31
000182870 773__ $$0PERI:(DE-600)2589522-9$$gVol. 12, no. 10$$n10$$p4789-4801$$tAmerican journal of cancer research$$v12$$x2156-6976$$y2022
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