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@ARTICLE{Himbert:182870,
      author       = {C. Himbert and W. Z. Stephens and B. Gigic and S. Hardikar
                      and A. N. Holowatyj and T. Lin and J. Ose and E. Swanson and
                      A. Ashworth and C. A. Warby and A. R. Peoples and D. Nix and
                      J. Jedrzkiewicz and M. Bronner and B. Pickron and C. Scaife
                      and J. N. Cohan and P. Schrotz-King$^*$ and N. Habermann and
                      J. Boehm and M. Hullar and J. C. Figueiredo and A. T.
                      Toriola and E. M. Siegel and C. I. Li and A. B. Ulrich and
                      D. Shibata and K. Boucher and L. C. Huang and M. Schneider
                      and J. L. Round and C. M. Ulrich},
      title        = {{D}ifferences in the gut microbiome by physical activity
                      and {BMI} among colorectal cancer patients.},
      journal      = {American journal of cancer research},
      volume       = {12},
      number       = {10},
      issn         = {2156-6976},
      address      = {Madison, Wis.},
      publisher    = {e-Century Publ.},
      reportid     = {DKFZ-2022-02976},
      pages        = {4789-4801},
      year         = {2022},
      note         = {Am J Cancer Res 2022;12(10):4789-4801www.ajcr.us
                      /ISSN:2156-6976/ajcr0145332},
      abstract     = {Associations of energy balance components, including
                      physical activity and obesity, with colorectal cancer risk
                      and mortality are well established. However, the gut
                      microbiome has not been investigated as underlying
                      mechanism. We investigated associations of physical
                      activity, BMI, and combinations of physical activity/BMI
                      with gut microbiome diversity and differential abundances
                      among colorectal cancer patients. N=179 patients with
                      colorectal cancer (stages I-IV) were included in the study.
                      Pre-surgery stool samples were used to perform 16S rRNA gene
                      sequencing (Illumina). Physical activity (MET hrs/wk) during
                      the year before diagnosis was assessed by questionnaire and
                      participants were classified as being active vs. inactive
                      based on guidelines. BMI at baseline was abstracted from
                      medical records. Patients were classified into four
                      combinations of physical activity levels/BMI. Lower gut
                      microbial diversity was observed among 'inactive' vs.
                      'active' patients (Shannon: P=0.01, Simpson: P=0.03),
                      'obese' vs. 'normal weight' patients (Shannon, Simpson, and
                      Observed species: P=0.02, respectively), and
                      'overweight/obese/inactive' vs. 'normal weight/active'
                      patients (Shannon: P=0.02, Observed species: P=0.04).
                      Results differed by sex and tumor site. Two phyla and 12
                      genera (Actinobacteria and Fusobacteria, Adlercreutzia,
                      Anaerococcus, Clostridium, Eubacterium, Mogibacteriaceae,
                      Olsenella, Peptinophilus, Pyramidobacter, RFN20,
                      Ruminococcus, Succinivibrio, Succiniclasticum) were
                      differentially abundant across physical activity and BMI
                      groups. This is the first evidence for associations of
                      physical activity with gut microbiome diversity and
                      abundances, directly among colorectal cancer patients. Our
                      results indicate that physical activity may offset gut
                      microbiome dysbiosis due to obesity. Alterations in gut
                      microbiota may contribute mechanistically to the energy
                      balance-colorectal cancer link and impact clinical
                      outcomes.},
      keywords     = {Colorectal cancer (Other) / energy balance (Other) /
                      microbiome (Other) / obesity (Other) / physical activity
                      (Other)},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36381318},
      pmc          = {pmc:PMC9641409},
      url          = {https://inrepo02.dkfz.de/record/182870},
}