%0 Journal Article
%A Mynarek, Martin
%A Obrecht, Denise
%A Sill, Martin
%A Sturm, Dominik
%A Kloth-Stachnau, Katja
%A Selt, Florian
%A Ecker, Jonas
%A von Hoff, Katja
%A Juhnke, Björn-Ole
%A Goschzik, Tobias
%A Pietsch, Torsten
%A Bockmayr, Michael
%A Kool, Marcel
%A von Deimling, Andreas
%A Witt, Olaf
%A Schüller, Ulrich
%A Benesch, Martin
%A Gerber, Nicolas U
%A Sahm, Felix
%A Jones, David
%A Korshunov, Andrey
%A Pfister, Stefan
%A Rutkowski, Stefan
%A Milde, Till
%T Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.
%J Acta neuropathologica
%V 145
%N 1
%@ 0001-6322
%C Heidelberg
%I Springer
%M DKFZ-2022-02988
%P 97-112
%D 2023
%Z #LA:B310# / 2023 Jan;145(1):97-112
%X Molecular groups of medulloblastoma (MB) are well established. Novel risk stratification parameters include Group 3/4 (non-WNT/non-SHH) methylation subgroups I-VIII or whole-chromosomal aberration (WCA) phenotypes. This study investigates the integration of clinical and molecular parameters to improve risk stratification of non-WNT/non-SHH MB. Non-WNT/non-SHH MB from the HIT2000 study and the HIT-MED registries were selected based on availability of DNA-methylation profiling data. MYC or MYCN amplification and WCA of chromosomes 7, 8, and 11 were inferred from methylation array-based copy number profiles. In total, 403 non-WNT/non-SHH MB were identified, 346/403 (86
%K Group 3/4 (Other)
%K Medulloblastoma (Other)
%K Non-WNT/non-SHH (Other)
%K Risk stratification (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36459208
%R 10.1007/s00401-022-02522-4
%U https://inrepo02.dkfz.de/record/182882