TY  - JOUR
AU  - Mynarek, Martin
AU  - Obrecht, Denise
AU  - Sill, Martin
AU  - Sturm, Dominik
AU  - Kloth-Stachnau, Katja
AU  - Selt, Florian
AU  - Ecker, Jonas
AU  - von Hoff, Katja
AU  - Juhnke, Björn-Ole
AU  - Goschzik, Tobias
AU  - Pietsch, Torsten
AU  - Bockmayr, Michael
AU  - Kool, Marcel
AU  - von Deimling, Andreas
AU  - Witt, Olaf
AU  - Schüller, Ulrich
AU  - Benesch, Martin
AU  - Gerber, Nicolas U
AU  - Sahm, Felix
AU  - Jones, David
AU  - Korshunov, Andrey
AU  - Pfister, Stefan
AU  - Rutkowski, Stefan
AU  - Milde, Till
TI  - Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.
JO  - Acta neuropathologica
VL  - 145
IS  - 1
SN  - 0001-6322
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2022-02988
SP  - 97-112
PY  - 2023
N1  - #LA:B310# / 2023 Jan;145(1):97-112
AB  - Molecular groups of medulloblastoma (MB) are well established. Novel risk stratification parameters include Group 3/4 (non-WNT/non-SHH) methylation subgroups I-VIII or whole-chromosomal aberration (WCA) phenotypes. This study investigates the integration of clinical and molecular parameters to improve risk stratification of non-WNT/non-SHH MB. Non-WNT/non-SHH MB from the HIT2000 study and the HIT-MED registries were selected based on availability of DNA-methylation profiling data. MYC or MYCN amplification and WCA of chromosomes 7, 8, and 11 were inferred from methylation array-based copy number profiles. In total, 403 non-WNT/non-SHH MB were identified, 346/403 (86
KW  - Group 3/4 (Other)
KW  - Medulloblastoma (Other)
KW  - Non-WNT/non-SHH (Other)
KW  - Risk stratification (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36459208
DO  - DOI:10.1007/s00401-022-02522-4
UR  - https://inrepo02.dkfz.de/record/182882
ER  -