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@ARTICLE{Liu:182895,
      author       = {I. Liu and L. Jiang and E. R. Samuelsson and S. Marco Salas
                      and A. Beck and O. A. Hack and D. Jeong and M. L. Shaw and
                      B. Englinger and J. LaBelle and H. M. Mire and S. Madlener
                      and L. Mayr and M. A. Quezada and M. Trissal and E.
                      Panditharatna and K. J. Ernst$^*$ and J. Vogelzang and T. A.
                      Gatesman and M. E. Halbert and H. Palova and P. Pokorna and
                      J. Sterba and O. Slaby and R. Geyeregger and A. Diaz and I.
                      J. Findlay and M. D. Dun and A. Resnick and M. L. Suvà and
                      D. T. W. Jones$^*$ and S. Agnihotri and J. Svedlund and C.
                      Koschmann and C. Haberler and T. Czech and I. Slavc and J.
                      A. Cotter and K. L. Ligon and S. Alexandrescu and W. K. A.
                      Yung and I. Arrillaga-Romany and J. Gojo and M. Monje and M.
                      Nilsson and M. G. Filbin},
      title        = {{T}he landscape of tumor cell states and spatial
                      organization in {H}3-{K}27{M} mutant diffuse midline glioma
                      across age and location.},
      journal      = {Nature genetics},
      volume       = {54},
      number       = {12},
      issn         = {1061-4036},
      address      = {London},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2022-02998},
      pages        = {1881-1894},
      year         = {2022},
      note         = {2022 Dec;54(12):1881-1894},
      abstract     = {Histone 3 lysine27-to-methionine (H3-K27M) mutations most
                      frequently occur in diffuse midline gliomas (DMGs) of the
                      childhood pons but are also increasingly recognized in
                      adults. Their potential heterogeneity at different ages and
                      midline locations is vastly understudied. Here, through
                      dissecting the single-cell transcriptomic, epigenomic and
                      spatial architectures of a comprehensive cohort of patient
                      H3-K27M DMGs, we delineate how age and anatomical location
                      shape glioma cell-intrinsic and -extrinsic features in light
                      of the shared driver mutation. We show that stem-like
                      oligodendroglial precursor-like cells, present across all
                      clinico-anatomical groups, display varying levels of
                      maturation dependent on location. We reveal a previously
                      underappreciated relationship between mesenchymal cancer
                      cell states and age, linked to age-dependent differences in
                      the immune microenvironment. Further, we resolve the spatial
                      organization of H3-K27M DMG cell populations and identify a
                      mitotic oligodendroglial-lineage niche. Collectively, our
                      study provides a powerful framework for rational modeling
                      and therapeutic interventions.},
      cin          = {B360},
      ddc          = {570},
      cid          = {I:(DE-He78)B360-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36471067},
      doi          = {10.1038/s41588-022-01236-3},
      url          = {https://inrepo02.dkfz.de/record/182895},
}