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000186218 0247_ $$2doi$$a10.1016/j.celrep.2022.111761
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000186218 041__ $$aEnglish
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000186218 1001_ $$aOrth, Martin F$$b0
000186218 245__ $$aSystematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation.
000186218 260__ $$a[New York, NY]$$bElsevier$$c2022
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000186218 520__ $$aEwing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although the paucity of additional mutations makes EwS a genuine model to study principles of cooperation between dominant fusion oncogenes and neo-enhancers, this is impeded by the limited number of well-characterized models. Here we present the Ewing Sarcoma Cell Line Atlas (ESCLA), comprising whole-genome, DNA methylation, transcriptome, proteome, and chromatin immunoprecipitation sequencing (ChIP-seq) data of 18 cell lines with inducible EWSR1-ETS knockdown. The ESCLA shows hundreds of EWSR1-ETS-targets, the nature of EWSR1-ETS-preferred GGAA mSats, and putative indirect modes of EWSR1-ETS-mediated gene regulation, converging in the duality of a specific but plastic EwS signature. We identify heterogeneously regulated EWSR1-ETS-targets as potential prognostic EwS biomarkers. Our freely available ESCLA (http://r2platform.com/escla/) is a rich resource for EwS research and highlights the power of comprehensive datasets to unravel principles of heterogeneous gene regulation by chimeric transcription factors.
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000186218 650_7 $$2Other$$aCP: Cancer
000186218 650_7 $$2Other$$aChiP-seq
000186218 650_7 $$2Other$$aEWSR1-ERG
000186218 650_7 $$2Other$$aEWSR1-ETS
000186218 650_7 $$2Other$$aEWSR1-FLI1
000186218 650_7 $$2Other$$aEwing sarcoma
000186218 650_7 $$2Other$$aenhancer
000186218 650_7 $$2Other$$amicrosatellites
000186218 650_7 $$2Other$$amulti-omics
000186218 650_7 $$2Other$$apediatric sarcoma
000186218 650_7 $$2Other$$atumor heterogeneity
000186218 7001_ $$aSurdez, Didier$$b1
000186218 7001_ $$0P:(DE-He78)40245f2168b87c014e445cabf610fd46$$aFaehling, Tobias$$b2$$udkfz
000186218 7001_ $$0P:(DE-He78)9b3d0cef2b1553fc9d2c5f24d91c12e1$$aEhlers, Anna$$b3$$udkfz
000186218 7001_ $$aMarchetto, Aruna$$b4
000186218 7001_ $$aGrossetête, Sandrine$$b5
000186218 7001_ $$aVolckmann, Richard$$b6
000186218 7001_ $$aZwijnenburg, Danny A$$b7
000186218 7001_ $$aGerke, Julia S$$b8
000186218 7001_ $$aZaidi, Sakina$$b9
000186218 7001_ $$aAlonso, Javier$$b10
000186218 7001_ $$aSastre, Ana$$b11
000186218 7001_ $$aBaulande, Sylvain$$b12
000186218 7001_ $$0P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b$$aSill, Martin$$b13$$udkfz
000186218 7001_ $$0P:(DE-HGF)0$$aCidre-Aranaz, Florencia$$b14
000186218 7001_ $$0P:(DE-He78)c25b54b0c834093d1f884d2615e305d6$$aOhmura, Shunya$$b15$$udkfz
000186218 7001_ $$0P:(DE-He78)fd68f49dada874ac262fadf9fde869df$$aKirchner, Thomas$$b16$$udkfz
000186218 7001_ $$aHauck, Stefanie M$$b17
000186218 7001_ $$aReischl, Eva$$b18
000186218 7001_ $$aGymrek, Melissa$$b19
000186218 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b20$$udkfz
000186218 7001_ $$aStrauch, Konstantin$$b21
000186218 7001_ $$aKoster, Jan$$b22
000186218 7001_ $$aDelattre, Olivier$$b23
000186218 7001_ $$0P:(DE-He78)7a590ab95c6f7ba52880452da78ecd6c$$aGrünewald, Thomas$$b24$$eLast author$$udkfz
000186218 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2022.111761$$gVol. 41, no. 10, p. 111761 -$$n10$$p111761$$tCell reports$$v41$$x2211-1247$$y2022
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