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| 001 | 186218 | ||
| 005 | 20240229145736.0 | ||
| 024 | 7 | _ | |a 10.1016/j.celrep.2022.111761 |2 doi |
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| 100 | 1 | _ | |a Orth, Martin F |b 0 |
| 245 | _ | _ | |a Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation. |
| 260 | _ | _ | |a [New York, NY] |c 2022 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1670848912_19724 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #LA:B410# |
| 520 | _ | _ | |a Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although the paucity of additional mutations makes EwS a genuine model to study principles of cooperation between dominant fusion oncogenes and neo-enhancers, this is impeded by the limited number of well-characterized models. Here we present the Ewing Sarcoma Cell Line Atlas (ESCLA), comprising whole-genome, DNA methylation, transcriptome, proteome, and chromatin immunoprecipitation sequencing (ChIP-seq) data of 18 cell lines with inducible EWSR1-ETS knockdown. The ESCLA shows hundreds of EWSR1-ETS-targets, the nature of EWSR1-ETS-preferred GGAA mSats, and putative indirect modes of EWSR1-ETS-mediated gene regulation, converging in the duality of a specific but plastic EwS signature. We identify heterogeneously regulated EWSR1-ETS-targets as potential prognostic EwS biomarkers. Our freely available ESCLA (http://r2platform.com/escla/) is a rich resource for EwS research and highlights the power of comprehensive datasets to unravel principles of heterogeneous gene regulation by chimeric transcription factors. |
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| 650 | _ | 7 | |a CP: Cancer |2 Other |
| 650 | _ | 7 | |a ChiP-seq |2 Other |
| 650 | _ | 7 | |a EWSR1-ERG |2 Other |
| 650 | _ | 7 | |a EWSR1-ETS |2 Other |
| 650 | _ | 7 | |a EWSR1-FLI1 |2 Other |
| 650 | _ | 7 | |a Ewing sarcoma |2 Other |
| 650 | _ | 7 | |a enhancer |2 Other |
| 650 | _ | 7 | |a microsatellites |2 Other |
| 650 | _ | 7 | |a multi-omics |2 Other |
| 650 | _ | 7 | |a pediatric sarcoma |2 Other |
| 650 | _ | 7 | |a tumor heterogeneity |2 Other |
| 700 | 1 | _ | |a Surdez, Didier |b 1 |
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| 700 | 1 | _ | |a Ehlers, Anna |0 P:(DE-He78)9b3d0cef2b1553fc9d2c5f24d91c12e1 |b 3 |u dkfz |
| 700 | 1 | _ | |a Marchetto, Aruna |b 4 |
| 700 | 1 | _ | |a Grossetête, Sandrine |b 5 |
| 700 | 1 | _ | |a Volckmann, Richard |b 6 |
| 700 | 1 | _ | |a Zwijnenburg, Danny A |b 7 |
| 700 | 1 | _ | |a Gerke, Julia S |b 8 |
| 700 | 1 | _ | |a Zaidi, Sakina |b 9 |
| 700 | 1 | _ | |a Alonso, Javier |b 10 |
| 700 | 1 | _ | |a Sastre, Ana |b 11 |
| 700 | 1 | _ | |a Baulande, Sylvain |b 12 |
| 700 | 1 | _ | |a Sill, Martin |0 P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b |b 13 |u dkfz |
| 700 | 1 | _ | |a Cidre-Aranaz, Florencia |0 P:(DE-HGF)0 |b 14 |
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| 700 | 1 | _ | |a Hauck, Stefanie M |b 17 |
| 700 | 1 | _ | |a Reischl, Eva |b 18 |
| 700 | 1 | _ | |a Gymrek, Melissa |b 19 |
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| 700 | 1 | _ | |a Strauch, Konstantin |b 21 |
| 700 | 1 | _ | |a Koster, Jan |b 22 |
| 700 | 1 | _ | |a Delattre, Olivier |b 23 |
| 700 | 1 | _ | |a Grünewald, Thomas |0 P:(DE-He78)7a590ab95c6f7ba52880452da78ecd6c |b 24 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.celrep.2022.111761 |g Vol. 41, no. 10, p. 111761 - |0 PERI:(DE-600)2649101-1 |n 10 |p 111761 |t Cell reports |v 41 |y 2022 |x 2211-1247 |
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