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@ARTICLE{Teubner:186246,
      author       = {L. Teubner and R. Frantz and L. La Pietra and M. Hudel and
                      J. Bazant and G. Lochnit and L. Eismann$^*$ and G.
                      Kramer$^*$ and T. Chakraborty and M. Abu Mraheil},
      title        = {{S}ec{A}2 {A}ssociates with {T}ranslating {R}ibosomes and
                      {C}ontributes to the {S}ecretion of {P}otent {IFN}-β
                      {I}nducing {RNA}s.},
      journal      = {International journal of molecular sciences},
      volume       = {23},
      number       = {23},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2022-03040},
      pages        = {15021},
      year         = {2022},
      note         = {DKFZ-ZMBH Alliance},
      abstract     = {Protein secretion plays a central role in modulating
                      interactions of the human pathogen Listeria monocytogenes
                      with its environment. Recently, secretion of RNA has emerged
                      as an important strategy used by the pathogen to manipulate
                      the host cell response to its advantage. In general, the
                      Sec-dependent translocation pathway is a major route for
                      protein secretion in L. monocytogenes, but mechanistic
                      insights into the secretion of RNA by these pathways are
                      lacking. Apart from the classical SecA1 secretion pathway,
                      L. monocytogenes also encodes for a SecA paralogue (SecA2)
                      which targets the export of a specific subset of proteins,
                      some of which are involved in virulence. Here, we
                      demonstrated that SecA2 co-sediments with translating
                      ribosomes and provided evidence that it associates with a
                      subset of secreted small non-coding RNAs (sRNAs) that induce
                      high levels of IFN-β response in host cells. We found that
                      enolase, which is translocated by a SecA2-dependent
                      mechanism, binds to several sRNAs, suggesting a pathway by
                      which sRNAs are targeted to the supernatant of L.
                      monocytogenes.},
      keywords     = {IFN-beta (Other) / Listeria monocytogenes (Other) / SecA2
                      (Other) / secreted RNA (Other)},
      cin          = {A250},
      ddc          = {540},
      cid          = {I:(DE-He78)A250-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36499346},
      doi          = {10.3390/ijms232315021},
      url          = {https://inrepo02.dkfz.de/record/186246},
}