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@ARTICLE{Sachpekidis:186247,
      author       = {C. Sachpekidis$^*$ and L. Pan$^*$ and A. Kopp-Schneider$^*$
                      and V. Weru$^*$ and J. C. Hassel and A.
                      Dimitrakopoulou-Strauss$^*$},
      title        = {{A}pplication of the long axial field-of-view {PET}/{CT}
                      with low-dose [18{F}]{FDG} in melanoma.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {50},
      number       = {4},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DKFZ-2022-03041},
      pages        = {1158-1167},
      year         = {2023},
      note         = {#EA:E060#LA:E060# / 2023 Mar;50(4):1158-1167},
      abstract     = {The recent introduction of long axial field-of-view (LAFOV)
                      PET/CT scanners has yielded very promising results regarding
                      image quality and sensitivity in oncological patients. We,
                      herein, aim to determine an appropriate acquisition time
                      range for the new long axial field of view Biograph Vision
                      Quadra PET/CT (Siemens Healthcare) using low dose [18F]FDG
                      activity in a group of melanoma patients.Forty-nine melanoma
                      patients were enrolled in the study. All patients underwent
                      total body PET/CT from the top of the head through the feet
                      in two bed positions (field-of-view 106 cm) after i.v.
                      injection of 2.0 MBq/kg [18F]FDG. The PET images of the
                      first bed position (head to upper thigh; PET-10) were
                      reconstructed and further split into 8-min (PET-8), 6-min
                      (PET-6), 5-min (PET-5), 4-min (PET-4), and 2-min (PET-2)
                      duration groups. Comparisons were performed between the
                      different reconstructed scan times with regard to the visual
                      evaluation of the PET/CT scans using the PET-10 images as
                      reference and by calculating the $95\%-CI$ for the
                      differences between different time acquisitions. Moreover,
                      objective evaluation of PET/CT image quality was performed
                      based on SUV calculations of tumor lesions and background,
                      leading to calculation of liver signal-to-noise ratio (SNR),
                      and tumor-to-background ratio (TBR).A total of 60 scans were
                      evaluated. Concerning visual analysis, 49/60 $(81.7\%)$
                      PET-10 scans were pathological, while the respective
                      frequencies were 49/60 $(81.7\%)$ for PET-8 $(95\%-CI:$ -
                      0.0602-0.0602), 49/60 $(81.7\%)$ for PET-6 $(95\%-CI:$ -
                      0.0602-0.0602), 48/60 $(80\%)$ for PET-5 $(95\%-CI:$ -
                      0.0445-0.0886), 46/60 $(76.7\%)$ for PET-4 $(95\%-CI:$ -
                      0.0132-0.1370), and 45/60 $(75\%)$ for PET-2 $(95\%-CI:$
                      0.0025-0.1593). In 18 PET-10 scans, the extent of metastatic
                      involvement was very large, rendering the accurate
                      calculation of [18F]FDG-avid tumor lesions very complicated.
                      In the remaining 42 PET-10 scans, for which the exact
                      calculation of tumor lesions was feasible, a total of 119
                      tumor lesions were counted, and the respective lesion
                      detection rates for shorter acquisitions were as follows:
                      $97.5\%$ (116/119) for PET-8 $(95\%-CI:$ 0-1), $95.0\%$
                      (113/119) for PET-6 $(95\%-CI:$ 0-1), $89.9\%$ (107/119) for
                      PET-5 $(95\%-CI:$ 0-2), $83.2\%$ (99/119) for PET-4
                      $(95\%-CI:$ 1-2), and $73.9\%$ (88/119) for PET-2
                      $(95\%-CI:$ 2-4). With regard to objective image quality
                      evaluations, as a general trend, the reduction of
                      acquisition time was associated with a decrease of liver SNR
                      and a decrease of TBR, although in lesion-based analysis the
                      change in TBR and tumor SUVmean values was non-significant
                      up to 6 and 5 min acquisitions, respectively.In melanoma,
                      low-dose LAFOV PET/CT imaging is feasible and can reduce the
                      total scan time from head to upper thigh up to 5 min
                      providing comparable diagnostic data to standard lengths of
                      acquisition. This may have significant implications for the
                      diagnostic work-up of patients with melanoma, given the need
                      for true whole-body imaging in this type of cancer.},
      keywords     = {LAFOV PET/CT (Other) / Melanoma (Other) / SUV (Other) /
                      Total body (Other) / Whole-body (Other) / [18F]FDG (Other)},
      cin          = {E060 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E060-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36474125},
      doi          = {10.1007/s00259-022-06070-7},
      url          = {https://inrepo02.dkfz.de/record/186247},
}