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000186298 037__ $$aDKFZ-2022-03087
000186298 041__ $$aEnglish
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000186298 1001_ $$0P:(DE-He78)8267c7c8b2e91db98a49f832eb5b99bb$$aJin, Fukang$$b0$$eFirst author$$udkfz
000186298 245__ $$aCirculating tumour cells in patients with lung cancer universally indicate poor prognosis.
000186298 260__ $$aSheffield$$bSoc.$$c2022
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000186298 520__ $$aIn lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to CTC subtypes, cut-offs and time points of CTC enumeration.We searched MEDLINE, Web of Science and Embase alongside relevant studies evaluating the prognostic value of CTCs in lung cancer patients. A random-effects model was used for meta-analysis, calculating hazard ratios (HRs), 95% confidence intervals and p-values.27 studies enrolling 2957 patients were included. CTC detection indicates poor prognosis, especially in small cell lung cancer (SCLC) patients (overall survival HR 3.11, 95% CI 2.59-3.73) and predicts a worse outcome compared to nonsmall cell lung cancer patients. Epithelial CTCs predict a worse outcome for lung cancer than mesenchymal CTCs or epithelial-mesenchymal hybrids.CTCs indicate poor prognosis in patients with primary lung cancer, with CTCs in SCLC having a more pronounced prognostic effect. The prognostic value of CTCs detected by different markers varies; most evidence is available for the strong negative prognostic effect of epithelial CTCs.
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000186298 650_7 $$2NLM Chemicals$$aBiomarkers, Tumor
000186298 650_2 $$2MeSH$$aHumans
000186298 650_2 $$2MeSH$$aNeoplastic Cells, Circulating: pathology
000186298 650_2 $$2MeSH$$aLung Neoplasms: pathology
000186298 650_2 $$2MeSH$$aCarcinoma, Non-Small-Cell Lung
000186298 650_2 $$2MeSH$$aPrognosis
000186298 650_2 $$2MeSH$$aBiomarkers, Tumor
000186298 7001_ $$00000-0002-0060-1776$$aZhu, Lei$$b1$$eFirst author
000186298 7001_ $$aShao, Jingbo$$b2
000186298 7001_ $$0P:(DE-He78)3cced3b69a277d5f5ff0b8cc93495e2f$$aYakoub, Mina$$b3$$udkfz
000186298 7001_ $$0P:(DE-He78)5ebf27c73a3f0b66abe1c471997cebb8$$aSchmitt, Lukas$$b4$$udkfz
000186298 7001_ $$aReißfelder, Christoph$$b5
000186298 7001_ $$0P:(DE-He78)1eee9e84c0f8c90a97fe40b6e8252a23$$aLoges, Sonja$$b6$$udkfz
000186298 7001_ $$00000-0002-7238-6956$$aBenner, Axel$$b7
000186298 7001_ $$00000-0003-0012-3177$$aSchölch, Sebastian$$b8$$eLast author
000186298 773__ $$0PERI:(DE-600)2202947-3$$a10.1183/16000617.0151-2022$$gVol. 31, no. 166, p. 220151 -$$n166$$p220151$$tEuropean respiratory review$$v31$$x0905-9180$$y2022
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