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@ARTICLE{Jin:186298,
      author       = {F. Jin$^*$ and L. Zhu$^*$ and J. Shao and M. Yakoub$^*$ and
                      L. Schmitt$^*$ and C. Reißfelder and S. Loges$^*$ and A.
                      Benner$^*$ and S. Schölch$^*$},
      title        = {{C}irculating tumour cells in patients with lung cancer
                      universally indicate poor prognosis.},
      journal      = {European respiratory review},
      volume       = {31},
      number       = {166},
      issn         = {0905-9180},
      address      = {Sheffield},
      publisher    = {Soc.},
      reportid     = {DKFZ-2022-03087},
      pages        = {220151},
      year         = {2022},
      note         = {#EA:A430#LA:A430#},
      abstract     = {In lung cancer, the relevance of various circulating tumour
                      cell (CTC) subgroups in different lung cancer subtypes is
                      unclear. We performed a comprehensive meta-analysis to
                      assess the prognostic value of CTCs in the different
                      histological types of lung cancer, with particular respect
                      to CTC subtypes, cut-offs and time points of CTC
                      enumeration.We searched MEDLINE, Web of Science and Embase
                      alongside relevant studies evaluating the prognostic value
                      of CTCs in lung cancer patients. A random-effects model was
                      used for meta-analysis, calculating hazard ratios (HRs),
                      $95\%$ confidence intervals and p-values.27 studies
                      enrolling 2957 patients were included. CTC detection
                      indicates poor prognosis, especially in small cell lung
                      cancer (SCLC) patients (overall survival HR 3.11, $95\%$ CI
                      2.59-3.73) and predicts a worse outcome compared to nonsmall
                      cell lung cancer patients. Epithelial CTCs predict a worse
                      outcome for lung cancer than mesenchymal CTCs or
                      epithelial-mesenchymal hybrids.CTCs indicate poor prognosis
                      in patients with primary lung cancer, with CTCs in SCLC
                      having a more pronounced prognostic effect. The prognostic
                      value of CTCs detected by different markers varies; most
                      evidence is available for the strong negative prognostic
                      effect of epithelial CTCs.},
      subtyp        = {Review Article},
      keywords     = {Humans / Neoplastic Cells, Circulating: pathology / Lung
                      Neoplasms: pathology / Carcinoma, Non-Small-Cell Lung /
                      Prognosis / Biomarkers, Tumor / Biomarkers, Tumor (NLM
                      Chemicals)},
      cin          = {A430 / A420 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)A430-20160331 / I:(DE-He78)A420-20160331 /
                      I:(DE-He78)C060-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36517047},
      doi          = {10.1183/16000617.0151-2022},
      url          = {https://inrepo02.dkfz.de/record/186298},
}