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024 7 _ |a 10.1183/16000617.0151-2022
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100 1 _ |a Jin, Fukang
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245 _ _ |a Circulating tumour cells in patients with lung cancer universally indicate poor prognosis.
260 _ _ |a Sheffield
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520 _ _ |a In lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to CTC subtypes, cut-offs and time points of CTC enumeration.We searched MEDLINE, Web of Science and Embase alongside relevant studies evaluating the prognostic value of CTCs in lung cancer patients. A random-effects model was used for meta-analysis, calculating hazard ratios (HRs), 95% confidence intervals and p-values.27 studies enrolling 2957 patients were included. CTC detection indicates poor prognosis, especially in small cell lung cancer (SCLC) patients (overall survival HR 3.11, 95% CI 2.59-3.73) and predicts a worse outcome compared to nonsmall cell lung cancer patients. Epithelial CTCs predict a worse outcome for lung cancer than mesenchymal CTCs or epithelial-mesenchymal hybrids.CTCs indicate poor prognosis in patients with primary lung cancer, with CTCs in SCLC having a more pronounced prognostic effect. The prognostic value of CTCs detected by different markers varies; most evidence is available for the strong negative prognostic effect of epithelial CTCs.
536 _ _ |a 311 - Zellbiologie und Tumorbiologie (POF4-311)
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650 _ 7 |a Biomarkers, Tumor
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Neoplastic Cells, Circulating: pathology
|2 MeSH
650 _ 2 |a Lung Neoplasms: pathology
|2 MeSH
650 _ 2 |a Carcinoma, Non-Small-Cell Lung
|2 MeSH
650 _ 2 |a Prognosis
|2 MeSH
650 _ 2 |a Biomarkers, Tumor
|2 MeSH
700 1 _ |a Zhu, Lei
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700 1 _ |a Shao, Jingbo
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700 1 _ |a Yakoub, Mina
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700 1 _ |a Schmitt, Lukas
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700 1 _ |a Reißfelder, Christoph
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700 1 _ |a Loges, Sonja
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700 1 _ |a Benner, Axel
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700 1 _ |a Schölch, Sebastian
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773 _ _ |a 10.1183/16000617.0151-2022
|g Vol. 31, no. 166, p. 220151 -
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