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@ARTICLE{Lu:186306,
      author       = {Y. Lu and Y. C. Zhao and J. Chang-Claude$^*$ and S. B.
                      Gruber and A. Gsur and K. Offit and L. Vodickova and M. O.
                      Woods and L. H. Nguyen and K. H. Wade and R. Carreras-Torres
                      and V. Moreno and D. D. Buchanan and M. Cotterchio and A. T.
                      Chan and A. I. Phipps and U. Peters and M. Song},
      title        = {{G}enetic {P}redictors for {F}ecal {P}ropionate and
                      {B}utyrate-{P}roducing {M}icrobiome {P}athway are {N}ot
                      {A}ssociated with {C}olorectal {C}ancer {R}isk: {A}
                      {M}endelian {R}andomization {A}nalysis.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {32},
      number       = {2},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2022-03095},
      pages        = {281-286},
      year         = {2023},
      note         = {2023 Feb 6;32(2):281-286},
      abstract     = {Mechanistic data indicate the benefit of short-chain fatty
                      acids (SCFAs) produced by gut microbial fermentation of
                      fiber on colorectal cancer (CRC), but direct epidemiological
                      evidence is limited. A recent study identified single
                      nucleotide polymorphisms (SNPs) for two SCFA traits (fecal
                      propionate and butyrate-producing microbiome pathway
                      PWY-5022) in Europeans and showed metabolic benefits.We
                      conducted a two-sample Mendelian randomization (MR) analysis
                      of the genetic instruments for the two SCFA traits (three
                      SNPs for fecal propionate and nine for PWY-5022) in relation
                      to CRC risk in three large European genetic consortia of
                      58,131 CRC cases and 67,347 controls. We estimated the risk
                      of overall CRC and conducted subgroup analyses by sex, age,
                      and anatomical subsites of CRC.We did not observe strong
                      evidence for an association of the genetic predictors for
                      fecal propionate levels and the abundance of PWY-5022 with
                      the risk of overall CRC, CRC by sex, or early-onset CRC (CRC
                      diagnosed at <50 years), with no evidence of heterogeneity
                      or pleiotropy. When assessed by tumor subsites, we found
                      weak evidence for an association between PWY-5022 and risk
                      of rectal cancer (OR per 1-SD=0.95, $95\%$ CI=0.91-0.99;
                      P=0.03) but it did not surpass multiple testing of subgroup
                      analysis.Genetic instruments for fecal propionate levels and
                      the abundance of PWY-5022 were not associated with CRC
                      risk.Fecal propionate and PWY-5022 may not have a
                      substantial influence on CRC risk. Future research is
                      warranted to comprehensively investigate the effects of
                      SCFA-producing bacteria and SCFAs on CRC risk.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36512731},
      doi          = {10.1158/1055-9965.EPI-22-0861},
      url          = {https://inrepo02.dkfz.de/record/186306},
}