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@INBOOK{Thomsen:186335,
      author       = {A. R. Thomsen$^*$ and M. R. Saalmann and N. Nicolay$^*$ and
                      A.-L. Grosu$^*$ and P. Vaupel$^*$},
      title        = {{I}mproved {O}xygenation of {H}uman {S}kin, {S}ubcutis and
                      {S}uperficial {C}ancers {U}pon {M}ild {H}yperthermia
                      {D}elivered by {WIRA}-{I}rradiation.},
      volume       = {1395},
      address      = {Cham},
      publisher    = {Springer International Publishing},
      reportid     = {DKFZ-2022-03103},
      isbn         = {978-3-031-14189-8 (print)},
      series       = {Advances in Experimental Medicine and Biology},
      pages        = {255 - 261},
      year         = {2022},
      comment      = {Oxygen Transport to Tissue XLIII / Scholkmann, Felix
                      (Editor) ; Cham : Springer International Publishing, 2022,
                      Chapter 42 ; ISSN: 0065-2598=2214-8019 ; ISBN:
                      978-3-031-14189-8=978-3-031-14190-4 ;
                      doi:10.1007/978-3-031-14190-4},
      booktitle     = {Oxygen Transport to Tissue XLIII /
                       Scholkmann, Felix (Editor) ; Cham :
                       Springer International Publishing,
                       2022, Chapter 42 ; ISSN:
                       0065-2598=2214-8019 ; ISBN:
                       978-3-031-14189-8=978-3-031-14190-4 ;
                       doi:10.1007/978-3-031-14190-4},
      abstract     = {Clinical trials have shown that mild hyperthermia (HT)
                      serves as an adjunct to cancer treatments such as chemo- and
                      radiotherapy. Recently, a high efficacy of mild HT
                      immediately followed by hypofractionated radiotherapy (RT)
                      in treatment of recurrent breast cancer has been documented
                      if temperatures of 39-43 °C are achieved for 40-60 min. In
                      the present study, temperature and oxygenation profiles were
                      measured in superficial tissues of healthy volunteers
                      exposed to water-filtered infrared-A- (wIRA)- irradiation,
                      to verify that adequate thermal doses together with the
                      improved tumor oxygenation necessary for radiosensitisation
                      are obtained. Experiments were performed using a wIRA-system
                      equipped with two wIRA-radiators, each with a thermography
                      camera for real-time monitoring of the skin surface
                      temperature. Temperatures within the abdominal wall were
                      measured with fibre optic sensors at defined tissue depths
                      (subepidermal, and 1-20 mm inside the tissue). The
                      corresponding tissue pO2 values were assessed with
                      fluorometric microsensors. In selected situations,
                      hyperspectral tissue imaging was used to visualise the
                      oxygenation status of normal skin and superficial tumours in
                      patients. Pre-treatment skin surface temperature was 34.6
                      °C. Upon wIRA exposure, average skin surface temperatures
                      reached 41.6 °C within 5-12 min. Maximum tissue
                      temperatures of 41.8 °C were found at a tissue depth of 1
                      mm, with a steady decline in deeper tissue layers (41.6 °C
                      @ 5 mm, 40.8 °C @ 10 mm, 40.6 °C @ 15 mm, and 40.1 °C @
                      20 mm). Effective HT levels ≥39 °C were established in
                      tissue depths up to 25 mm. Tissue heating was accompanied by
                      a significant increase in tissue pO2 values [e.g., at a
                      tissue depth of 13 mm mean pO2 rose from 46 mmHg to 81 mmHg
                      (@ T = 40.5 °C). In the post-heating phase (+ 5 min), pO2
                      was 79 mmHg (@ T = 38 °C) and 15 min post-heat pO2 was 72
                      mmHg (@ T = 36.8 °C)]. pO2 values remained elevated for
                      30-60 min post-heat. Non-invasive monitoring of normal skin
                      and of recurrent breast cancers confirmed the improved O2
                      status by wIRA-HT. In conclusion, wIRA-irradiation enables
                      effective tissue heating (T = 39-43 °C) associated with
                      distinct increases in blood flow and pO2. These adjustments
                      unequivocally meet the requirement for effective
                      radiosensitisation.},
      keywords     = {Hypofractionated radiotherapy (Other) / Radiosensitizatiom
                      (Other) / Thermography (Other) / Water-filtered
                      infrared-A-(wIRA) irradiation (Other)},
      cin          = {FR01 / E055},
      ddc          = {570},
      cid          = {I:(DE-He78)FR01-20160331 / I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)7},
      pubmed       = {pmid:36527646},
      doi          = {10.1007/978-3-031-14190-4_42},
      url          = {https://inrepo02.dkfz.de/record/186335},
}