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@ARTICLE{Vit:186337,
      author       = {G. Vit$^*$ and A. Hirth$^*$ and N. Neugebauer$^*$ and B. N.
                      Kraft$^*$ and G. Sigismondo$^*$ and A. Cazzola$^*$ and C.
                      Tessmer$^*$ and J. Duro and J. Krijgsveld$^*$ and I.
                      Hofmann$^*$ and M. Berger and H. Klüter and C. Niehrs$^*$
                      and J. Nilsson and A. Krämer$^*$},
      title        = {{H}uman {SLFN}5 and its {X}enopus {L}aevis ortholog
                      regulate entry into mitosis and oocyte meiotic resumption.},
      journal      = {Cell death discovery},
      volume       = {8},
      number       = {1},
      issn         = {2058-7716},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2022-03105},
      pages        = {484},
      year         = {2022},
      note         = {#EA:A360#LA:A360# / DKFZ-ZMBH Alliance},
      abstract     = {The Schlafen gene family was first described in mice as a
                      regulator of thymocyte development. Further studies showed
                      involvement of human orthologs in different processes
                      related with viral replication, cellular proliferation, and
                      differentiation. In recent years, a new role for human
                      Slfn11 in DNA replication and chromatin remodeling was
                      described. As commonly observed in many gene families, Slfn
                      paralogs show a tissue-specific expression. This made it
                      difficult to reach conclusions which can be valid in
                      different biological models regarding the function of the
                      different Schlafen proteins. In the present study, we
                      investigate the involvement of SLFN5 in cell-cycle
                      regulation and cell proliferation. A careful analysis of
                      SLFN5 expression revealed that SLFN5 is highly expressed in
                      proliferating tissues and that the protein is ubiquitously
                      present in all the tissues and cell line models we analyzed.
                      Very interestingly, SLFN5 expression oscillates during cell
                      cycle, peaking during S phase. The fact that SLFN5 interacts
                      with protein phosphatase 2A and that SLFN5 depletion causes
                      cell cycle arrest and cellular apoptosis, suggests a direct
                      involvement of this human paralog in cell cycle progression
                      and cellular proliferation. We substantiated our in vitro
                      and in cellulo results using Xenopus laevis oocytes to show
                      that mRNA depletion of the unique Slfn gene present in
                      Xenopus, whose protein sequence shares $80\%$ of homology
                      with SLFN5, recapitulates the phenotype observed in human
                      cells preventing the resumption of meiosis during oocyte
                      development.},
      cin          = {A360 / A050 / B230 / W170},
      ddc          = {610},
      cid          = {I:(DE-He78)A360-20160331 / I:(DE-He78)A050-20160331 /
                      I:(DE-He78)B230-20160331 / I:(DE-He78)W170-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36477080},
      pmc          = {pmc:PMC9729291},
      doi          = {10.1038/s41420-022-01274-0},
      url          = {https://inrepo02.dkfz.de/record/186337},
}