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000186399 0247_ $$2doi$$a10.1091/mbc.E20-03-0179
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000186399 0247_ $$2ISSN$$a1044-2030
000186399 0247_ $$2ISSN$$a1939-4586
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000186399 041__ $$aEnglish
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000186399 1001_ $$aCaydasi, Ayse Koca$$b0
000186399 245__ $$aSWR1 Chromatin Remodeling Complex Prevents Mitotic Slippage during Spindle Position Checkpoint Arrest.
000186399 260__ $$aBethesda, Md.$$bAmerican Society for Cell Biology$$c2023
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000186399 520__ $$aFaithful chromosome segregation in budding yeast requires correct positioning of the mitotic spindle along the mother to daughter cell polarity axis. When the anaphase spindle is not correctly positioned, a surveillance mechanism, named as the spindle position checkpoint (SPOC), prevents the progression out of mitosis until correct spindle positioning is achieved. How SPOC works on a molecular level is not well understood. Here, we performed a genome-wide genetic screen to search for components required for SPOC. We identified the SWR1 chromatin-remodeling complex (SWR1-C) among several novel factors that are essential for SPOC integrity. Cells lacking SWR1-C were able to activate SPOC upon spindle misorientation but underwent mitotic slippage upon prolonged SPOC arrest. This mitotic slippage required the Cdc14-early anaphase release pathway and other factors including the SAGA histone acetyltransferase complex, proteasome components and the mitotic cyclin-dependent kinase inhibitor Sic1. Together, our data establish a novel link between SWR1-C chromatin remodeling and robust checkpoint arrest in late anaphase.
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000186399 7001_ $$aKhmelinskii, Anton$$b1
000186399 7001_ $$aDarieva, Zoulfia$$b2
000186399 7001_ $$aKurtulmus, Bahtiyar$$b3
000186399 7001_ $$aKnop, Michael$$b4
000186399 7001_ $$0P:(DE-He78)5138c10dcd0901d001d67a31423402b5$$aPereira, Gislene$$b5$$eLast author$$udkfz
000186399 773__ $$0PERI:(DE-600)1474922-1$$a10.1091/mbc.E20-03-0179$$gp. mbc.E20-03-0179$$n2$$par11b$$tMolecular biology of the cell$$v34$$x1059-1524$$y2023
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000186399 9141_ $$y2022
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