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@ARTICLE{Caydasi:186399,
      author       = {A. K. Caydasi and A. Khmelinskii and Z. Darieva and B.
                      Kurtulmus and M. Knop and G. Pereira$^*$},
      title        = {{SWR}1 {C}hromatin {R}emodeling {C}omplex {P}revents
                      {M}itotic {S}lippage during {S}pindle {P}osition
                      {C}heckpoint {A}rrest.},
      journal      = {Molecular biology of the cell},
      volume       = {34},
      number       = {2},
      issn         = {1059-1524},
      address      = {Bethesda, Md.},
      publisher    = {American Society for Cell Biology},
      reportid     = {DKFZ-2022-03166},
      pages        = {ar11b},
      year         = {2023},
      note         = {DKFZ-ZMBH Alliance / 2023 Feb 1;34(2):ar11b / #LA:A180#},
      abstract     = {Faithful chromosome segregation in budding yeast requires
                      correct positioning of the mitotic spindle along the mother
                      to daughter cell polarity axis. When the anaphase spindle is
                      not correctly positioned, a surveillance mechanism, named as
                      the spindle position checkpoint (SPOC), prevents the
                      progression out of mitosis until correct spindle positioning
                      is achieved. How SPOC works on a molecular level is not well
                      understood. Here, we performed a genome-wide genetic screen
                      to search for components required for SPOC. We identified
                      the SWR1 chromatin-remodeling complex (SWR1-C) among several
                      novel factors that are essential for SPOC integrity. Cells
                      lacking SWR1-C were able to activate SPOC upon spindle
                      misorientation but underwent mitotic slippage upon prolonged
                      SPOC arrest. This mitotic slippage required the Cdc14-early
                      anaphase release pathway and other factors including the
                      SAGA histone acetyltransferase complex, proteasome
                      components and the mitotic cyclin-dependent kinase inhibitor
                      Sic1. Together, our data establish a novel link between
                      SWR1-C chromatin remodeling and robust checkpoint arrest in
                      late anaphase.},
      cin          = {A180},
      ddc          = {570},
      cid          = {I:(DE-He78)A180-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36542480},
      doi          = {10.1091/mbc.E20-03-0179},
      url          = {https://inrepo02.dkfz.de/record/186399},
}