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| 001 | 186399 | ||
| 005 | 20240229145746.0 | ||
| 024 | 7 | _ | |a 10.1091/mbc.E20-03-0179 |2 doi |
| 024 | 7 | _ | |a pmid:36542480 |2 pmid |
| 024 | 7 | _ | |a 1059-1524 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2022-03166 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Caydasi, Ayse Koca |b 0 |
| 245 | _ | _ | |a SWR1 Chromatin Remodeling Complex Prevents Mitotic Slippage during Spindle Position Checkpoint Arrest. |
| 260 | _ | _ | |a Bethesda, Md. |c 2023 |b American Society for Cell Biology |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1674658774_18725 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a DKFZ-ZMBH Alliance / 2023 Feb 1;34(2):ar11b / #LA:A180# |
| 520 | _ | _ | |a Faithful chromosome segregation in budding yeast requires correct positioning of the mitotic spindle along the mother to daughter cell polarity axis. When the anaphase spindle is not correctly positioned, a surveillance mechanism, named as the spindle position checkpoint (SPOC), prevents the progression out of mitosis until correct spindle positioning is achieved. How SPOC works on a molecular level is not well understood. Here, we performed a genome-wide genetic screen to search for components required for SPOC. We identified the SWR1 chromatin-remodeling complex (SWR1-C) among several novel factors that are essential for SPOC integrity. Cells lacking SWR1-C were able to activate SPOC upon spindle misorientation but underwent mitotic slippage upon prolonged SPOC arrest. This mitotic slippage required the Cdc14-early anaphase release pathway and other factors including the SAGA histone acetyltransferase complex, proteasome components and the mitotic cyclin-dependent kinase inhibitor Sic1. Together, our data establish a novel link between SWR1-C chromatin remodeling and robust checkpoint arrest in late anaphase. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 700 | 1 | _ | |a Khmelinskii, Anton |b 1 |
| 700 | 1 | _ | |a Darieva, Zoulfia |b 2 |
| 700 | 1 | _ | |a Kurtulmus, Bahtiyar |b 3 |
| 700 | 1 | _ | |a Knop, Michael |b 4 |
| 700 | 1 | _ | |a Pereira, Gislene |0 P:(DE-He78)5138c10dcd0901d001d67a31423402b5 |b 5 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1091/mbc.E20-03-0179 |g p. mbc.E20-03-0179 |0 PERI:(DE-600)1474922-1 |n 2 |p ar11b |t Molecular biology of the cell |v 34 |y 2023 |x 1059-1524 |
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| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)5138c10dcd0901d001d67a31423402b5 |
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