% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Chen:186453,
      author       = {X. Chen$^*$ and H. Li$^*$ and M. Mandic$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{A}ssessment of {B}ody {M}ass {I}ndex, {P}olygenic {R}isk
                      {S}core, and {D}evelopment of {C}olorectal {C}ancer.},
      journal      = {JAMA network open},
      volume       = {5},
      number       = {12},
      issn         = {2574-3805},
      address      = {Chicago, Ill.},
      publisher    = {American Medical Association},
      reportid     = {DKFZ-2022-03174},
      pages        = {e2248447 -},
      year         = {2022},
      note         = {#EA:C070#LA:C070#LA:C120#},
      abstract     = {Excess weight, the prevalence of which is high and
                      increasing in many countries, is linked to multiple adverse
                      health outcomes, including increased colorectal cancer (CRC)
                      risk. Better communication of health risks associated with
                      excess weight might support efforts of prevention.To
                      evaluate the individual and joint associations of body mass
                      index (BMI) and polygenic risk with CRC, to assess potential
                      interactions among them, and to quantify by how much
                      increased polygenic risk for CRC can be offset by having a
                      BMI within reference range.This population-based
                      case-control study was conducted in the Rhine-Neckar region
                      of southwest Germany, with recruitment from 2003 to 2017.
                      Participants with both risk factor and genetic information
                      were included for analysis. Data analysis was conducted from
                      December 8, 2021, to February 17, 2022.BMI was calculated as
                      self-reported weight in kilograms approximately 10 years
                      before diagnosis or interview and current height in meters
                      squared. A polygenic risk score (PRS) was built based on 140
                      CRC-related risk loci.Individual and joint associations of
                      BMI and PRS with CRC were estimated using multiple logistic
                      regression. Associations of excess weight with CRC were
                      quantified by adjusted odds ratios (aORs) and genetic risk
                      equivalents (GREs), the equivalent outcomes conveyed by
                      defined differences in PRS percentiles.Among 9169
                      participants (median [IQR] age, 69 [62-76] years; 5589
                      $[61.0\%]$ male participants) included, 5053 had CRC and
                      4116 did not. BMI of 30 or greater was associated with
                      higher odds of having CRC compared with BMI less than 25
                      (aOR, 1.71; $95\%$ CI, 1.49-1.97), independent of PRS levels
                      (P for interaction = .45). Participants with BMI of 30 or
                      greater and a PRS in the highest tertile had higher odds of
                      CRC compared with participants with BMI less than 25 and a
                      PRS in the lowest tertile (aOR, 3.82; $95\%$ CI, 3.03-4.82).
                      The estimated association of BMI greater than 30 with CRC
                      risk was equivalent to that of having a 41 $(95\%$ CI,
                      29-53)-percentile higher PRS. BMI of 30 or greater was
                      particularly associated with stage IV CRC (aOR, 2.21; $95\%$
                      CI, 1.71-2.84).These findings suggest that excess weight was
                      associated with CRC regardless of PRS levels. The
                      association of having a BMI within reference range may be
                      similar to that of having a substantially lower polygenic
                      risk for CRC.},
      keywords     = {Humans / Male / Aged / Female / Body Mass Index /
                      Case-Control Studies / Risk Factors / Weight Gain /
                      Colorectal Neoplasms: epidemiology / Colorectal Neoplasms:
                      genetics},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36547977},
      doi          = {10.1001/jamanetworkopen.2022.48447},
      url          = {https://inrepo02.dkfz.de/record/186453},
}