%0 Journal Article
%A Giaccherini, Matteo
%A Farinella, Riccardo
%A Gentiluomo, Manuel
%A Mohelnikova-Duchonova, Beatrice
%A Kauffmann, Emanuele Federico
%A Palmeri, Matteo
%A Uzunoglu, Faik
%A Soucek, Pavel
%A Petrauskas, Dalius
%A Cavestro, Giulia Martina
%A Zykus, Romanas
%A Carrara, Silvia
%A Pezzilli, Raffaele
%A Puzzono, Marta
%A Szentesi, Andrea
%A Neoptolemos, John
%A Archibugi, Livia
%A Palmieri, Orazio
%A Milanetto, Anna Caterina
%A Capurso, Gabriele
%A van Eijck, Casper H J
%A Stocker, Hannah
%A Lawlor, Rita T
%A Vodicka, Pavel
%A Lovecek, Martin
%A Izbicki, Jakob R
%A Perri, Francesco
%A Kupcinskaite-Noreikiene, Rita
%A Götz, Mara
%A Kupcinskas, Juozas
%A Hussein, Tamás
%A Hegyi, Péter
%A Busch, Olivier R
%A Hackert, Thilo
%A Mambrini, Andrea
%A Brenner, Hermann
%A Lucchesi, Maurizio
%A Basso, Daniela
%A Tavano, Francesca
%A Schöttker, Ben
%A Vanella, Giuseppe
%A Bunduc, Stefania
%A Petrányi, Ágota
%A Landi, Stefano
%A Morelli, Luca
%A Canzian, Federico
%A Campa, Daniele
%T Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk.
%J International journal of cancer
%V 153
%N 2
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2022-03199
%P 373-379
%D 2023
%Z 2023 Jul 15;153(2):373-379
%X Genes carrying high-penetrance germline mutations may also be associated with cancer susceptibility through common low-penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the common genetic variability of PDAC familial genes was analysed in our study. We conducted a multiphase study analysing 7745 single nucleotide polymorphisms (SNPs) from 29 genes reported to harbour a high-penetrance PDAC-associated mutation in at least one published study. To assess the effect of the SNPs on PDAC risk, a total of 14 666 PDAC cases and 221 897 controls across five different studies were analysed. The T allele of the rs1412832 polymorphism, that is situated in the CDKN2B-AS1/ANRIL, showed a genome-wide significant association with increased risk of developing PDAC (OR = 1.11, 95
%K association study (Other)
%K genetic susceptibility (Other)
%K pancreatic ductal adenocarcinoma (Other)
%K single nucleotide polymorphisms (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36451333
%R 10.1002/ijc.34383
%U https://inrepo02.dkfz.de/record/186478