TY  - JOUR
AU  - Giaccherini, Matteo
AU  - Farinella, Riccardo
AU  - Gentiluomo, Manuel
AU  - Mohelnikova-Duchonova, Beatrice
AU  - Kauffmann, Emanuele Federico
AU  - Palmeri, Matteo
AU  - Uzunoglu, Faik
AU  - Soucek, Pavel
AU  - Petrauskas, Dalius
AU  - Cavestro, Giulia Martina
AU  - Zykus, Romanas
AU  - Carrara, Silvia
AU  - Pezzilli, Raffaele
AU  - Puzzono, Marta
AU  - Szentesi, Andrea
AU  - Neoptolemos, John
AU  - Archibugi, Livia
AU  - Palmieri, Orazio
AU  - Milanetto, Anna Caterina
AU  - Capurso, Gabriele
AU  - van Eijck, Casper H J
AU  - Stocker, Hannah
AU  - Lawlor, Rita T
AU  - Vodicka, Pavel
AU  - Lovecek, Martin
AU  - Izbicki, Jakob R
AU  - Perri, Francesco
AU  - Kupcinskaite-Noreikiene, Rita
AU  - Götz, Mara
AU  - Kupcinskas, Juozas
AU  - Hussein, Tamás
AU  - Hegyi, Péter
AU  - Busch, Olivier R
AU  - Hackert, Thilo
AU  - Mambrini, Andrea
AU  - Brenner, Hermann
AU  - Lucchesi, Maurizio
AU  - Basso, Daniela
AU  - Tavano, Francesca
AU  - Schöttker, Ben
AU  - Vanella, Giuseppe
AU  - Bunduc, Stefania
AU  - Petrányi, Ágota
AU  - Landi, Stefano
AU  - Morelli, Luca
AU  - Canzian, Federico
AU  - Campa, Daniele
TI  - Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk.
JO  - International journal of cancer
VL  - 153
IS  - 2
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2022-03199
SP  - 373-379
PY  - 2023
N1  - 2023 Jul 15;153(2):373-379
AB  - Genes carrying high-penetrance germline mutations may also be associated with cancer susceptibility through common low-penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the common genetic variability of PDAC familial genes was analysed in our study. We conducted a multiphase study analysing 7745 single nucleotide polymorphisms (SNPs) from 29 genes reported to harbour a high-penetrance PDAC-associated mutation in at least one published study. To assess the effect of the SNPs on PDAC risk, a total of 14 666 PDAC cases and 221 897 controls across five different studies were analysed. The T allele of the rs1412832 polymorphism, that is situated in the CDKN2B-AS1/ANRIL, showed a genome-wide significant association with increased risk of developing PDAC (OR = 1.11, 95
KW  - association study (Other)
KW  - genetic susceptibility (Other)
KW  - pancreatic ductal adenocarcinoma (Other)
KW  - single nucleotide polymorphisms (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36451333
DO  - DOI:10.1002/ijc.34383
UR  - https://inrepo02.dkfz.de/record/186478
ER  -