%0 Journal Article
%A Peterziel, Heike
%A Jamaladdin, Nora
%A ElHarouni, Dina
%A Gerloff, Xenia
%A Herter, Sonja
%A Fiesel, Petra
%A Berker, Yannick
%A Blattner-Johnson, Mirjam
%A Schramm, Kathrin
%A Jones, Barbara
%A Reuss, David
%A Turunen, Laura
%A Friedenauer, Aileen
%A Holland-Letz, Tim
%A Sill, Martin
%A Weiser, Lena
%A Previti, Christopher
%A Balasubramanian, Gnanaprakash
%A Gerber, Nicolas U
%A Gojo, Johannes
%A Hutter, Caroline
%A Øra, Ingrid
%A Lohi, Olli
%A Kattamis, Antonis
%A de Wilde, Bram
%A Westermann, Frank
%A Tippelt, Stephan
%A Graf, Norbert
%A Nathrath, Michaela
%A Sparber-Sauer, Monika
%A Sehested, Astrid
%A Kramm, Christof M
%A Dirksen, Uta
%A Kallioniemi, Olli
%A Pfister, Stefan
%A van Tilburg, Cornelis Martinus
%A Jones, David
%A Saarela, Jani
%A Pietiäinen, Vilja
%A Jäger, Natalie
%A Schlesner, Matthias
%A Kopp-Schneider, Annette
%A Oppermann, Sina
%A Milde, Till
%A Witt, Olaf
%A Oehme, Ina
%T Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM.
%J npj precision oncology
%V 6
%N 1
%@ 2397-768X
%C [London]
%I Springer Nature
%M DKFZ-2022-03215
%P 94
%D 2022
%Z #EA:B310#LA:B310#
%X The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75-78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on multicellular fresh tumor tissue spheroid cultures in 384-well plates with an overall mean processing time of three weeks. In 89 cases (67
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36575299
%R 10.1038/s41698-022-00335-y
%U https://inrepo02.dkfz.de/record/186513